Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity.
When applied with the 0.25-0.5 ppm Pt/PVP-colloid in RW or HW, the level of DPPH radicals decreased to 77.5-59.6% or 16.1-5.6%, in contrast to the level as high as 81.3% for HW alone, respectively, as measured by an electron spin resonance method. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreAdvanced research on the health benefit of reduced water
This narrative review examined the available evidence on molecular hydrogen. It has been suggested that the active agents in reduced water are hydrogen (atoms and molecules), mineral nanoparticles, and mineral nanoparticle hydrides. This publication was a narrative review rather than a controlled therapeutic trial, and it presented several proposed active agents without establishing all of them as definitive mechanisms. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness. This narrative review summarizes laboratory and animal evidence and discusses limitations of the available literature and the need for additional controlled research. It is included as Related Mechanisms & Background Science under H2HUBB's early hydrogen-water policy. It should not be presented as a single controlled therapeutic trial, and claims about molecular hydrogen must remain tied to the evidence reviewed by the authors. Further research is needed to clarify clinical relevance.
Read MoreAntioxidants and K+ channel agonists versus hydrogen therapy during ex vivo lung perfusion†.
Antioxidants and K+ channel agonists versus hydrogen therapy during ex vivo lung perfusion†
Read MoreElectrochemically reduced water protects neural cells from oxidative damage.
In In the present study, the protective effect of ERW against hydrogen peroxide (H₂O₂) and nitric oxide (NO) was investigated in several rodent neuronal cell lines and primary cells, eRW was found to significantly suppress H₂O₂ (50-200 μM) induced PC12 and SFME cell deaths. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance. This electrochemically reduced-water cellular study is included under H2HUBB's early hydrogen-water policy. The original intervention should remain accurately labeled, and no dissolved-H₂ dose should be inferred if it was not reported.
Read MoreSuppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells.
In It has been demonstrated that hydrogen peroxide (H(2)O(2)) is directly associated with elevated matrix metalloproteinase-2 (MMP-2) expression in several cell lines, electrochemically reduced water (ERW), produced near the cathode during electrolysis, and scavenges intracellular H(2)O(2) in human fibrosarcoma HT1080 cells. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance. This electrolyzed-reduced-water cellular study is included under H2HUBB's early hydrogen-water policy. The original intervention should be reported as electrochemically reduced water, without claiming a measured H₂ dose unless the source reports one.
Read MoreTelomere Shortening in Cancer Cells by Electrolyzed-Reduced Water
Electrolyzed-reduced water altered growth and telomere-related measurements in cultured A549 and HeLa cancer cells, while the reported telomerase activity did not materially change. This is a cell-culture observation and does not show that the water shortens tumors' telomeres or treats cancer in animals or people.
Read MoreHydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage
Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage Compared to cells pretreated without hydrogen, the researchers demonstrated that treating cells with hydrogen-rich PBS before irradiation could significantly inhibit IR-induced apoptosis, increase viability of human intestinal crypt cells, significantly increase endogenous antioxidant, and decrease malondialdehyde and 8-hydroxydeoxyguanosine concentrations of human lymphocyte AHH-1 cells. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreNeutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression.
NHE water diminished hydroxyl radicals as demonstrated by ESR in a cell-free system. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance. This cellular study evaluated neutral-pH hydrogen-enriched electrolyzed water. Oxidant and peroxide-related terminology describes the experimental outcome rather than the identity of the intervention.
Read MoreAtomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo.
This animal study examined Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. The abstract describes Animal model. The abstract reports: We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells.
This in vitro or cellular study examined PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells. The abstract describes Cell culture / in vitro model. The abstract reports: Using inhibitor of p38, we found that regulation of the p38/glycogen synthase kinase 3β (GSK3β)/Nrf-2 axis was involved in the protective effects of PGC-1α. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of glutathione on oxidative injury induced by hydrogen peroxide in intestinal epithelial cells.
This in vitro or cellular study examined Protective effects of glutathione on oxidative injury induced by hydrogen peroxide in intestinal epithelial cells. The abstract describes Epithelial cell model. The abstract reports: GSH appears to ameliorate oxidative injury in intestinal epithelial cells by attenuating HO-mediated activation of NF-κB and P38 MAPK signaling pathways that regulate intestinal…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAn Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress
Corneal alkali burns are potentially blinding injuries. Alkali induces oxidative stress in corneas followed by excessive corneal inflammation, neovascularization, and untransparent scar formation. Molecular hydrogen (H), a potent reactive oxygen species (ROS) scavenger, suppresses oxidative stress and enables corneal healing when applied on the corneal surface.
Read MoreHydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition.
This in vitro or cellular study examined Hydrogen treatment prevents lipopolysaccharide-induced pulmonary endothelial cell dysfunction through RhoA inhibition. The abstract describes Endothelial cell model. The abstract reports: Our findings suggest that RhoA is a crucial protein in the signaling pathway of LPS-induced endothelial cell dysfunction. Hydrogen treatment can prevent LPS-induced junctional…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen peroxide inhibits the growth of lung cancer cells via the induction of cell death and G1‑phase arrest.
This in vitro or cellular study examined Hydrogen peroxide inhibits the growth of lung cancer cells via the induction of cell death and G1‑phase arrest. The abstract describes A549 cell model. The abstract reports: Cells treated with H2O2 demonstrated a considerable G1‑phase arrest of the cell cycle. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCombined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4.
Combined treatment with H₂ and Pt-nc resulted in an approximately 200-fold increase in intracellular ROS levels compared with the control, whereas the suppressive effect of tumor cell growth was abrogated entirely by catalase treatment in NUGC-4 cells. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance. The intervention included dissolved molecular hydrogen and platinum nanocolloid. The design does not isolate the contribution of H₂ from the platinum co-intervention, and hydrogen peroxide was a measured mechanistic outcome.
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