Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model.
Takuma Iwaki, Shinji Nakamura, Takayuki Wakabayashi, Yasuhiro Nakao, Yinmon Htun, Toui Tsuchiya, Tsutomu Mitsuie, Kosuke Koyano, Aya Morimoto, Noriko Fuke, Takayuki Yokota, Sonoko Kondo, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Iwase, Takashi Kusaka · Scientific reports · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, the total glomerular cell count was significantly higher in the HI group than in the other groups, with no difference between the HI-H₂ and control groups. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen was evaluated in this publication and summarizes the source-grounded findings below. The total glomerular cell count was significantly higher in the HI group than in the other groups, with no difference between the HI-H₂ and control groups.
What the Researchers Studied
The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
However, the ability of H₂ gas to ameliorate AKI is unknown. The researchers examined histopathological injuries in the piglet renal cortex on day 5 after a hypoxic-ischemic (HI) insult and if H₂ gas can alleviate kidney injuries. The total glomerular cell count was significantly higher in the HI group than in the other groups, with no difference between the HI-H₂ and control groups.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The study used a preclinical animal experiment.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.