Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model.
Toru Yoshiura, Satoko Kawauchi, Sho Nishida, Sho Sato, Daichi Hagita, Arumu Endo, Masaya Nakagawa, Takashi Fujii, Yohei Otsuka, Yumiko Mishima, Kazuya Fujii, Satoru Takeuchi, Arata Tomiyama, Terushige Toyooka, Shunichi Sato, Kojiro Wada · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, compared with controls, the H₂ and Mg groups had significantly reduced total depolarization and hypoperfusion times. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in rats. Compared with controls, the H₂ and Mg groups had significantly reduced total depolarization and hypoperfusion times.
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
The 1.3 % H₂ gas was administered via ventilator control. Compared with controls, the H₂ and Mg groups had significantly reduced total depolarization and hypoperfusion times. The authors concluded that these findings indicate that H₂ and Mg reduce key pathophysiological processes related to early brain injury and delayed cerebral ischemia following subarachnoid hemorrhage, potentially improving outcomes by minimizing depolarization events and associated ischemia.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.