Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation.
Bo Qi, Yu Song, Chen Chen, Lina Zhao, Wanjie Ma, Shuqi Meng, Xiaoli Zhuang, Huayi Lin, Jing Liang, Yan Cui, Keliang Xie · International immunopharmacology · 2023
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Independent study record
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H2HUBB TAKEAWAY
In mice, the survival rate, visual and spatial learning ability, and memory ability were improved in septic mice treated with H₂. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
This study explored the possible effects of H₂ on cognition and tau phosphorylation in a mouse model of SAE.
How Molecular Hydrogen Was Used
Mice treated with 2 % H₂ inhalation for 60 min at 1 h and 6 h after surgery, respectively.
What the Researchers Found
The survival rate, visual and spatial learning ability, and memory ability were improved in septic mice treated with H₂.
Biological or Mechanistic Findings
Molecular hydrogen (H₂) plays an antioxidant and anti-inflammatory role, and plays a protective role in septic mice.
Authors’ Conclusion
The authors concluded that the protective effect of H₂ on cognitive dysfunction induced by SAE may be achieved by inhibiting tau phosphorylation, which is perhaps related with the inhibition of TTBK1. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.