Molecular Hydrogen Research Library

H2HUBB SCIENTIFIC RESOURCE

Molecular Hydrogen Research Library

Explore molecular hydrogen research collected and organized by H2HUBB over more than a decade. Search studies by condition, evidence type, delivery method, author, journal, DOI, or PMID.

Library last updated: September 12, 2026

Research-use notice

This library summarizes published research for educational purposes. A study listing does not establish safety, effectiveness, or medical suitability for an individual.

2,028Published studies
287Human evidence records
294Reviews and meta-analyses
62Research topics

THE STORY BEHIND THE LIBRARY

Built from More Than a Decade of Research

The H2HUBB Molecular Hydrogen Research Library is a public collection of scientific publications gathered and organized by H2HUBB founder Tywon Hubbard over more than a decade of work in the molecular hydrogen field. These are sources he has used in research, education, product evaluation, and professional work, now made available in one searchable public resource.

This library reflects H2HUBB’s commitment to locating original sources, preserving accurate study information, and helping researchers, professionals, and consumers better understand the developing science of molecular hydrogen.

BROWSE THE DATABASE

Explore Molecular Hydrogen Research by Topic

RESEARCH RESULTS

2,028 Studies Found

Laboratory or cellular evidenceLaboratory StudyOther or not reported

Enteric-coated magnesium-propelled polymersome nanomotors for pH-triggered intestinal activation and mucosal IgA induction

Yu-Rim Ahn, Eulhae Ga, Subin Lee, Jaewon Choi, Minse Kim, SoJin Shin, HakSeon Kim, Seona Yu, Nanhyeon Kim, Jaehyun Hwang, Jaeseok Choi, Kwang Suk Lim, Suk-Jin Ha, Woonsung Na, Hyun-Ouk Kim · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026

In a laboratory model, after coating, the hydrodynamic diameter increased from 141.33 ± 3.62 nm to 188.63 ± 2.03 nm, confirming formation of a protective layer. These findings from a laboratory model add evidence…

Primary topic
Gastrointestinal Health
Delivery method
Other or not reported
Study ID
DOI: 10.1016/j.biopha.2026.119229
Laboratory or cellular evidenceLaboratory StudyOther or not reported

Engineering Pt-decorated g-C3N4 nanosheets with Fe3+ and chitosan for amplified photodynamic ROS production and hydrogen-mediated ATP depletion

Zahra Ahmadi, Sepideh Khoee, Samideh Khoei · International journal of biological macromolecules · 2026

In a laboratory model, the incorporation of platinum (Pt) nanoparticles with multiple oxidation states effectively improves charge separation, facilitates reactive oxygen species (ROS) generation, promotes H₂ and O₂ evolution, and induces intracellular GSH depletion.…

Primary topic
Oxidative Stress and Antioxidant Signaling
Delivery method
Other or not reported
Study ID
DOI: 10.1016/j.ijbiomac.2026.150278
Review or synthesisNarrative reviewOther or not reported

Research progress on the preventive and therapeutic effects of hydrogen in oxidative stress-induced pulmonary diseases

Zhilong Liu, Pei Zhao, Yufeng Kang, Wenjun Yan · Zhonghua wei zhong bing ji jiu yi xue · 2026

This narrative review examined recent research findings on the therapeutic application of H₂ in oxidative stress-related pulmonary diseases, aiming to provide theoretical foundations and research directions for the clinical application of H₂ in the…

Primary topic
Respiratory and Lung Health
Delivery method
Other or not reported
Study ID
DOI: 10.3760/cma.j.cn121430-20250611-00330
Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock—A Proof-of-Concept Study

Takahiro Yamanaka, Tadashi Matsuoka, Koichiro Homma, Tomoyoshi Tamura, Sayuri Suzuki, Shohei Suzuki, Daiki Kaito, Jo Yoshizawa, Keitaro Yajima, Soichiro Ono, Katsuya Maeshima, Eiji Kobayashi, Motoaki Sano, Junichi Sasaki · Biomedicines · 2026

In an animal model, increased hydrogen concentration in the portal vein indicated that hydrogen was delivered to the intestine. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in…

Primary topic
Gastrointestinal Health
Sample size
4
Delivery method
Other or not reported
Study ID
DOI: 10.3390/biomedicines14020455
Preclinical animal evidenceAnimal studyOther or not reported

A hydrogen-releasing polydopamine palladium hydride nanocoating protects airway mucosal injury induced by endotracheal tube cuff compression

Guo Mu, Huyang Du, Shuai Chen, Xinyu Chen, Qiang Li, Xuan Yu, Bin Lu, Yi Liu, Cheng Zhang · Biomaterials advances · 2026

In an animal model, the coating significantly reduced malondialdehyde and nitric oxide levels, enhanced superoxide dismutase activity, and protected mitochondrial integrity and cytoskeletal structure. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…

Primary topic
Respiratory and Lung Health
Delivery method
Other or not reported
Study ID
DOI: 10.1016/j.bioadv.2026.215037
Preclinical animal evidenceAnimal studyhydrogen-rich water

Efficacy of silicon-based agent against aging-related frailty

Yoshihisa Koyama, Yuki Kobayashi, Hikaru Kobayashi, Shoichi Shimada · Scientific reports · 2026

In aged C57BL/6J mice, the Si-based agent mitigated oxidative stress, suppressed motor performance and body weight decline, and reduced early mortality associated with age-related deterioration. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…

Primary topic
Aging and Longevity
Delivery method
hydrogen-rich water
Study ID
DOI: 10.1038/s41598-026-39711-0
Laboratory or cellular evidenceLaboratory StudyOther or not reported

Harnessing thermo-hydrogen coupling with palladium hydride nanoparticles for superior antitumor therapy

Xinyu Jiang, Kun Li, Penghui Zhao, Dong Li, Jinwen Shi, Yan Zhou, Fei Li, Bin Chen, Haiyan Chen · RSC advances · 2026

In summary, this study presents a PdH nanoparticle platform that achieves synergistic enhancement of oxidative stress in tumor cells through thermo-hydrogen coupling. These findings from a laboratory model add evidence supporting molecular hydrogen's biological…

Primary topic
Cancer and Supportive Oncology Research
Delivery method
Other or not reported
Study ID
DOI: 10.1039/d6ra02688e
Human clinical evidenceHuman Clinical StudyOther or not reported

Hybrid-Driven Bacillus Calmette–Guérin Carrier for Targeted Immuno-Chemo Combo Therapy in Bladder Cancer

Zhanxiang Zhang, Lin Wang, Zhongcheng An, Yuhang Jiang, Jiawen Niu, Laishou Yang, Qianqian Wang, Xinjian Fan, Tianlong Li · Cyborg and bionic systems (Washington, D.C.) · 2026

In Intravesical instillation of Bacillus Calmette-Guérin (BCG) combined with chemotherapy has been employed to improve bladder cancer treatment efficacy, but outcomes are often limited by high-dose drug, using a layer-by-layer assembly strategy, MRs were…

Primary topic
Cancer and Supportive Oncology Research
Delivery method
Other or not reported
Study ID
DOI: 10.34133/cbsystems.0492
Review or synthesisNarrative reviewOther or not reported

Synergistic Effects of Magnesium Ions and Hydrogen Gas in Biodegradable Mg Implants

Seyed Mohammad Hossein Mousavian, Vasily Anatolievich Bautin · Annals of biomedical engineering · 2026

This narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.

Primary topic
Oxidative Stress and Antioxidant Signaling
Delivery method
Other or not reported
Study ID
DOI: 10.1007/s10439-026-04001-3
Preclinical animal evidenceAnimal studyOther or not reported

Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair

Shengqiang Chen, Mingrui Luo, Sizhen Chen, Danyang Chen, Lingting Zeng, Lina Shangguan, Zhengji Sun, Guanglin Li, Wenjiang Ding, Wei Tang, Qianjun He · Cell stem cell · 2026

In an animal model, here, the researchers show that the viability and hyaline cartilage phenotype of bone marrow-derived mesenchymal stem cell (BMSC)-derived chondrocyte microspheroids (CMSs) can be efficiently preserved during spheroidization with persistent H₂…

Primary topic
Arthritis and Musculoskeletal Health
Delivery method
Other or not reported
Study ID
DOI: 10.1016/j.stem.2026.03.002
Showing 1–10 of 2,028 studies