research
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There are more than 2000 molecular hydrogen studies and publications worldwide indicating benefits for 170 human disease models
Here is a short list of some of our favorite studies on molecular hydrogen.
H2 Biomedical Research:
- Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles: https://medicalgasresearch.biomedcentral.com/articles/10.1186/s13618-015-0035-1
- Comprehensive Review Study on the Clinical Effects of Hydrogen: www.scirp.org/journal/PaperInformation.aspx?PaperID=62945
- Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications: https://www.ncbi.nlm.nih.gov/pubmed/25747486
- Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377272/
- Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine: http://www.sciencedirect.com/science/article/pii/S0163725814000941
- Molecular hydrogen: a therapeutic antioxidant and beyond: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223313/
- The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660246/
- Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207582/#b40-vhrm-10-591
- Effects of hydrogen-rich water on aging periodontal tissues in rats: http://www.nature.com/articles/srep05534
- Effects of hydrogen-rich water on depressive-like behavior in mice: http://www.nature.com/articles/srep23742
- Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B: http://onlinelibrary.wiley.com/doi/10.1111/cts.12076/full
- Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals: http://www.nature.com/nm/journal/v13/n6/full/nm1577.html
- Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679390/
- Hyperbaric hydrogen therapy: a possible treatment for cancer: https://www.ncbi.nlm.nih.gov/pubmed/1166304
- Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators: http://www.nature.com/articles/srep18971
- Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism: http://www.nature.com/articles/npjamd20168
- Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096212
- Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice: http://www.nature.com/articles/srep03273
- Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial: http://onlinelibrary.wiley.com/doi/10.1002/mds.25375/abstract
- The hydrogen highway to reperfusion therapy: http://www.nature.com/nm/journal/v13/n6/full/nm0607-673.html
- Allergies: Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells: https://www.ncbi.nlm.nih.gov/pubmed/19766097
- Antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals: https://www.ncbi.nlm.nih.gov/pubmed/17486089
- Anti-aging: Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells: https://www.jstage.jst.go.jp/article/circj/80/9/80_CJ-16-0227/_pdf
- Anti-aging (Lengthening telomeres, increases telomerase expression): Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase Activity: http://pubs.sciepub.com/ajfn/4/6/4/index.html#.WOHa_8Tp96g.facebook
- Anti-inflammatory: Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation: https://www.ncbi.nlm.nih.gov/pubmed/11510417
- Burns: Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation: https://www.ncbi.nlm.nih.gov/pubmed/26047940
- Burns: Protective effects of hydrogen against severe burns: http://www.molecularhydrogenstudies.com/protective-effects-of-hydrogen-against-severe-burns/
- Cholesterol: Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831093/
- Hay Fever: Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model: https://www.ncbi.nlm.nih.gov/pubmed/28215576
- High blood glucose: Role of hydrogen gas in regulating of poly (ADP-ribose) polymerase-1 dependent cell death in rat Schwann cells: https://www.ncbi.nlm.nih.gov/pubmed/27434555
- Neuropathic pain: H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain: https://www.ncbi.nlm.nih.gov/pubmed/25820467
- NrF2 Pathway (activates cell defense system): Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo: http://m.ajplung.physiology.org/content/304/10/L646.abstract
- Pain (reduces heightened sensitivity to pain): Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats: https://www.ncbi.nlm.nih.gov/pubmed/25241067
- Protects against Aspirin damage: Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925872/
- Protects against Tylenol damage: Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice: https://www.ncbi.nlm.nih.gov/pubmed/25892869
- Seasonal allergies: Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress: https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-016-0148-x
- Skin wrinkles: Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes: https://www.ncbi.nlm.nih.gov/pubmed/22070900
- Smoking: Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats: https://archive.org/details/pubmed-PMC3869805
- Smoking: Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury: https://www.researchgate.net/publication/277937758_Protective_Effects_of_Hydrogen-Rich_Saline_on_Rats_with_Smoke_Inhalation_Injury
- Supports immune system: The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice: https://www.ncbi.nlm.nih.gov/pubmed/19252295
- Supports immune system: Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119399/
- Wounds: Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699099/
- Oxidative stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101336/
- Oxidative Stress and Antioxidant Defense: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488923/
- Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation: https://www.ncbi.nlm.nih.gov/pubmed/22020111
- Oxidative stress in human diseases: https://www.ncbi.nlm.nih.gov/pubmed/18924487
- Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724665/
- Oxidative stress and psychological disorders: https://www.ncbi.nlm.nih.gov/pubmed/24669208
- Improves heart function: Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats: https://www.ncbi.nlm.nih.gov/pubmed/26849632
- Increased ATP production: Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration: http://onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2012.01542.x/full
- Increased ATP production: Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0108034
- Increased ATP production: Stimulation of human damaged sperm motility with hydrogen molecule: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300028/
- Increased Metabolism: Molecular hydrogen stimulates the gene expression of transcriptional co-activator PGC-1α to enhance fatty acid metabolism: http://www.nature.com/articles/npjamd20168
- Post recovery: Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes: https://www.researchgate.net/publication/306082536_Is_molecular_hydrogen_beneficial_to_enhance_post-exercise_recovery_in_female_athletes%20https://www.researchgate.net/publication/304667974_Molecular_Hydrogen_Affected_Post-Exercise_Recovery_in_Judo_Athletes_3820_Board_259_June_4_9_30_AM_-_11_00_AM
- Prevents cognitive decline: Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders: http://www.omicsgroup.org/journals/molecular-hydrogen-and-its-potential-application-in-therapy-of-brain-disorders-2168-975X.1000154.php?aid=36193 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872234/
- Prevents Muscle fatigue/reduces lactic acid: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes: http://www.ncbi.nlm.nih.gov/pubmed/22520831
- Selective antioxidant: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals: http://www.nature.com/nm/journal/v13/n6/full/nm1577.html
- Sport Medicine: Molecular hydrogen in sports medicine: new therapeutic perspectives: http://www.ncbi.nlm.nih.gov/pubmed/25525953
- Sport related injuries: Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries: http://www.ncbi.nlm.nih.gov/pubmed/25295663
H2 vs. Disease Models:
- Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563451/
- Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095341/
- Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788323/
- Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide: https://medicalgasresearch.biomedcentral.com/articles/10.1186/2045-9912-1-18
- Molecular hydrogen suppresses activated Wnt/β-catenin signaling: http://www.nature.com/articles/srep31986
- Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study: https://www.ncbi.nlm.nih.gov/pubmed/24929023
- Hydrogen-dissolved water inhibits growth of human tongue carcinoma cells: http://www.molecularhydrogenstudies.com/hydrogen-dissolved-water-inhibits-growth-of-human-tongue-carcinoma-cells/ , http://exp-oncology.com.ua/uploads/magazine/772.pdf?upload
- Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393812/
- Hyperbaric hydrogen therapy: A possible treatment for cancer: https://www.researchgate.net/publication/21989955_Hyperbaric_hydrogen_therapy_A_possible_treatment_for_cancer http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/2/2009210115846546222.pdf
- Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice: https://link.springer.com/article/10.1007/s00280-008-0924-2
- Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression: https://www.ncbi.nlm.nih.gov/pubmed/19192719
- Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386386/
- Telomere Shortening in Cancer Cells by Electrolyzed-Reduced Water: https://link.springer.com/chapter/10.1007%2F0-306-46869-7_62
- Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284969/
- Anti-Oxidative Water Improves Diabetes: https://link.springer.com/chapter/10.1007/978-94-010-0369-8_137#page-1
- Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat mode: http://download.springer.com/static/pdf/45/art%253A10.1186%252F2045-9912-1-26.pdf?originUrl=http%3A%2F%2Fmedicalgasresearch.biomedcentral.com%2Farticle%2F10.1186%2F2045-9912-1-26&token2=exp=1489680419~acl=%2Fstatic%2Fpdf%2F45%2Fart%25253A10.1186%25252F2045-9912-1-26.pdf*~hmac=07d76ed8438f56479eef94ea3b8046f1eda6f5daa17cc5213fc0a17c2ef9875d
- Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053913
- Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice: https://www.ncbi.nlm.nih.gov/pubmed/21293445
- Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance: https://www.ncbi.nlm.nih.gov/pubmed/19083400
- Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386384/
- Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress: https://www.ncbi.nlm.nih.gov/pubmed/22800834
- Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice: http://www.cardiovascularpathology.com/article/S1054-8807(15)00055-1/references
- Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?: https://www.ncbi.nlm.nih.gov/pubmed/19505462
- Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart: https://www.ncbi.nlm.nih.gov/pubmed/23771690
- Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats: http://www.heartlungcirc.org/article/S1443-9506(14)00800-2/references
- Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice: https://www.ncbi.nlm.nih.gov/pubmed/18996093?dopt=Abstract
- H2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model: http://jaha.ahajournals.org/content/1/5/e003459.full
- Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats: https://www.ncbi.nlm.nih.gov/pubmed/26849632
- Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway: https://www.spandidos-publications.com/mmr/10/2/1143
- Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081383/
- Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation: https://www.ncbi.nlm.nih.gov/pubmed/26565704
- Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice: http://www.cardiovascularpathology.com/article/S1054-8807(15)00055-1/references
- Hydrogen: another gas with therapeutic potential: http://www.kidney-international.org/article/S0085-2538(15)54214-2/fulltext
- Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation: https://www.ncbi.nlm.nih.gov/pubmed/27148060
- Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr/NDmcr rat kidney: https://www.researchgate.net/publication/229011208_Hydrogen-rich_water_inhibits_glucose_and_ab_-dicarbonyl_compound-induced_reactive_oxygen_species_production_in_the_SHRCg-LeprNDmcr_rat_kidney
- Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats: https://www.ncbi.nlm.nih.gov/pubmed/25592271
- Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats: https://academic.oup.com/ndt/article/26/7/2112/1895116/Intake-of-water-with-high-levels-of-dissolved
- The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives: https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-016-0036-0
- The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice: https://www.ncbi.nlm.nih.gov/pubmed/21570445
- Effects of hydrogen-rich water on depressive-like behavior in mice: http://www.nature.com/articles/srep23742
- Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans: https://link.springer.com/article/10.1007/s13530-016-0261-5
- Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism: https://www.researchgate.net/publication/232225514_Hydrogen_as_a_novel_hypothesized_emerging_treatment_for_oxidative_stress_in_autism
- Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress: https://www.ncbi.nlm.nih.gov/pubmed/20171955
- Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells: https://www.ncbi.nlm.nih.gov/pubmed/26271894
- Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680337/
- Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour in Mice: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042078
- Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464164/
- Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis: https://www.ncbi.nlm.nih.gov/pubmed/26537817
- Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407490/
- Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007247
- Hydrogen therapy: from mechanism to cerebral diseases: http://www.medgasres.com/article.asp?issn=2045-9912;year=2016;volume=6;issue=1;spage=48;epage=54;aulast=Liu
- Pilot study of H2 therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial: http://onlinelibrary.wiley.com/doi/10.1002/mds.25375/abstract
- Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pubmed/19356598
- Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease: https://www.hindawi.com/journals/pd/2011/307875/
- Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411925/
- Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298790/
- Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia: https://medicalgasresearch.biomedcentral.com/articles/10.1186/2045-9912-2-11
- The hydrogen highway to reperfusion therapy: http://www.nature.com/nm/journal/v13/n6/full/nm0607-673.html
For further research studies on molecular hydrogen please visit: www.molecularhydrogeninstitute.com
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