Smaller Inhalation Units
There have been a number of studies demonstrating that 1-1.3% (vol/vol) of H2 may offer therapeutic potential. That is equivalent to 50-78 mL/min @ 5‐6L/min gas exchange or ventilation minute. For this reason, we made this the absolute minimum threshold or standard for our recommendation for smaller inhalation units (e.g. portable devices).
“As demonstrated by studies, 1–4 % (v/v) H2 gas delivered through inhalation is effective as a treatment for I/R injury [72]” https://www.sciencedirect.com/science/article/pii/S0753332220307824
“from the National Cerebral and Cardiovascular Center (Osaka, Japan), which verified that inhalation of 1–4% hydrogen gas alleviated tissue damage and reduced the infarct size.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891106/
“They also showed that this aberrant oxidization of phospholipid was observed with a low concentration of hydrogen (at least 1.3 %), suggesting that the biological effects of hydrogen could be explained by the aberrant oxidation of phospholipid under hydrogen exposure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610055/
“In addition to hydrogen administration in water or saline, hydrogen-containing gas (HCG) (1.3% hydrogen + 20.8% oxygen + 77.9% nitrogen) is also a viable option.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/
“For example, one group reported that inhalation of 1% H2 gas or drinking H2 water attenuated the cisplatin-induced nephrotoxicity, mortality, and loss of body weight.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/
Until IHSA, develops H2 inhalation standards we have to set minimum standards based on the entirety of the current data. This minimum threshold or standard only applies for legitimate smaller inhalation units or portable inhalation units. Any recommended product that is approved at this mL/min minimum standard will be listed at a Tier 0 status. We also suggest these systems be worn with facial mask rather then nasal cannulas. This minimum standard will not apply for larger or flagship H2 inhalation systems, their minimum standard will remain 120 mL/min. Lastly, this standard is subject to change as the biomedical research of hydrogen progresses or if IHSA develops H2 inhalation standards.