PERFORMANCE LEVELS
HYDROGEN WATER
LEVEL 1 : This rating is awarded to those products that have achieved 0.8 – 1.9 mg of dissolved hydrogen in 1 liter of water.
LEVEL 2: This rating is awarded to those products that have achieved 2.0 – 3.9 mg of dissolved hydrogen in 1 liter of water.
LEVEL 3: This rating is awarded to those products that have achieved 4.0 – 5.9 mg of dissolved hydrogen in 1 liter of water.
LEVEL 4: This rating is awarded to those products that have achieved 6.0 – 10.0 mg of dissolved hydrogen in 1 liter of water.
hYDROGEN WATER PERFORMANCE RATINGS
Our hydrogen water performance levels (also sometimes referred to as Ingested H2 milligram rating) is solely based on a hydrogen water device and/or product maximum milligrams of dissolved hydrogen the device can provide in 1 liter of water. This is easily calculable by multiplying the H2 concentration (mg/L or ppm) by the volume of water in liters (L). The hydrogen water performance rating for our recommended products is based on the highest dissolved hydrogen concentration measured during our 1~3 month evaluation period. This measurement will be adjusted to its equivalent mg/L value to determine the maximum possible number of ingested milligrams if a person was to consume 1 liter of the water. The reason our up limit is 1 liter(L) of water is because that is the average amount of drinking water Americans consume daily [1] . Also, 1 liter provides us with a uniform standard for this metric and coincides well with the current scientific literature.
The performance rating system has 4 levels. These levels were developed based upon ingested milligram amounts seen through preclinical and clinical human studies. The ingested amounts of H2 range from 1 milligram to over 10 milligrams per day. Currently, the suggested milligram per day recommendation for dissolved hydrogen gas for humans is 1~3 mg/day. With this important information, we can assign a therapeutic value to the product or device based on the number of milligrams it can provide in 1 liter of water.
Our recommended product level rating will likely change periodically in order to reflect the dynamic nature of the therapeutic hydrogen industry, in which manufacturers are constantly improving products. We are fully aware there are many other metrics hydrogen water systems can be and are judged by. To view some of the standards by which we determine our recommendation, visit the Performance Standards page, and to view our product scores visit our Product Scores page which will help you know our opinion of the strengths and weaknesses of all of our recommended products.
HYDROGEN GAS
LEVEL 1: This rating is awarded to those products that have achieved our absolute minimum flow rate (mL/min) standard of 50-78 milliliters of hydrogen gas in 1 minute at >2%.
Smaller Inhalation Units
There have been a number of studies demonstrating that 1-1.3% (vol/vol) of H2 may offer therapeutic potential. That is equivalent to 50-78 mL/min @ 5‐6L/min gas exchange or ventilation minute. For this reason, we made this the absolute minimum threshold or standard for our recommendation for smaller inhalation units (e.g. portable devices).
“As demonstrated by studies, 1–4 % (v/v) H2 gas delivered through inhalation is effective as a treatment for I/R injury [72]” https://www.sciencedirect.com/science/article/pii/S0753332220307824
“from the National Cerebral and Cardiovascular Center (Osaka, Japan), which verified that inhalation of 1–4% hydrogen gas alleviated tissue damage and reduced the infarct size.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891106/
“They also showed that this aberrant oxidization of phospholipid was observed with a low concentration of hydrogen (at least 1.3 %), suggesting that the biological effects of hydrogen could be explained by the aberrant oxidation of phospholipid under hydrogen exposure. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610055/
“In addition to hydrogen administration in water or saline, hydrogen-containing gas (HCG) (1.3% hydrogen + 20.8% oxygen + 77.9% nitrogen) is also a viable option.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/
“For example, one group reported that inhalation of 1% H2 gas or drinking H2 water attenuated the cisplatin-induced nephrotoxicity, mortality, and loss of body weight.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/
Until IHSA, develops H2 inhalation standards we have to set minimum standards based on the entirety of the current data. This minimum threshold or standard only applies for legitimate smaller inhalation units or portable inhalation units. Any recommended product that is approved at this mL/min minimum standard will be listed at a Tier 0 status. We also suggest these systems be worn with facial mask rather then nasal cannulas. This minimum standard will not apply for larger or flagship H2 inhalation systems, their minimum standard will remain 120 mL/min. Lastly, this standard is subject to change as the biomedical research of hydrogen progresses or if IHSA develops H2 inhalation standards.
LEVEL 2: This rating is awarded to those products that have achieved 120-299 milliliters of hydrogen gas in 1 minute at >2%.
LEVEL 3: This rating is awarded to those products that have achieved 300-499 milliliters of hydrogen gas in 1 minute at >2%.
LEVEL 4: This rating is awarded to those products that have achieved 500-1000 milliliters of hydrogen gas in 1 minute at >2%.
hYDROGEN GAS PERFORMANCE RATINGS
Our hydrogen inhalation device performance levels (also sometimes referred to as H2 ml/min rating) is based solely on a hydrogen inhalation device’s maximum hydrogen milliliter per minute (ml/min) gas volume output and H2 gas percentage. The hydrogen gas output from an inhalation device is a critical performance metric for determining if the device will provide enough gas to be therapeutic for humans. The higher the gas output flow rate, the better the inhalation device will be at compensating for the losses of gas if inhaling via nasal cannula. Another important aspect we take into consideration when examining the performance capability of a unit is the H2 gas percentage (higher H2 concentrations in gas mixture), which can range from approximately 2% to 99.99%. The preliminary scientific data is suggesting that for H2 inhalation to be therapeutic, it needs to be at least in the range of 2~4% at normal resting breathing rates (5~6 L/min of gas exchange), which is equivalent to inhaling 120~240 ml/min of H2. Higher H2 percentages will result in faster saturation of the blood, thus also saturating cells, tissues, and organs faster. Understanding the above information provides us with a guide for assigning therapeutic value rankings for inhalation systems.
Our performance rating system has 4 levels. These levels (ratings) will likely change periodically in order to reflect the dynamic nature of the therapeutic hydrogen industry, in which manufacturers are constantly improving their products. We are fully aware there are many other metrics hydrogen inhalation systems can be and are judged by. To view some of the standards by which we determine our recommendation, visit the Performance Standards page, and to view our product scores visit our Product Scores page which will help you know our opinion of the strengths and weaknesses of all of our recommended products.
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