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Molecular Hydrogen Research Library

H2HUBB SCIENTIFIC RESOURCE

Molecular Hydrogen Research Library

Explore molecular hydrogen research collected and organized by H2HUBB over more than a decade. Search studies by condition, evidence type, delivery method, author, journal, DOI, or PMID.

Library last updated: August 14, 2026

Research-use notice

This library summarizes published research for educational purposes. A study listing does not establish safety, effectiveness, or medical suitability for an individual.

1,661Published studies
210Human evidence records
229Reviews and meta-analyses
41Research topics

THE STORY BEHIND THE LIBRARY

Built from More Than a Decade of Research

The H2HUBB Molecular Hydrogen Research Library is a public collection of scientific publications gathered and organized by H2HUBB founder Tywon Hubbard over more than a decade of work in the molecular hydrogen field. These are sources he has used in research, education, product evaluation, and professional work, now made available in one searchable public resource.

This library reflects H2HUBB’s commitment to locating original sources, preserving accurate study information, and helping researchers, professionals, and consumers better understand the developing science of molecular hydrogen.

BROWSE THE DATABASE

Explore Molecular Hydrogen Research by Topic

RESEARCH RESULTS

1,661 Studies Found

Human clinical evidenceHuman Clinical StudyOther or not reported

[The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome].

D D Pozdnyakova, I A Baranova, V D Selemir, O S Medvedev, A G Chuchalin · Terapevticheskii arkhiv · 2026

These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence fatigue-related outcomes.

Primary topic
Exercise, Athletics, and Recovery
Delivery method
Other or not reported
Main limitation
The automated source review did not identify a specific limitation statement; consult the full…
Study ID
DOI: 10.26442/00403660.2026.03.203537
View Study Full Text
Review or synthesisNarrative reviewOther or not reported

Preventable in-body hydrogen explosions from high-concentration H2 inhalers in Japan-Switch to safe, low-concentration hydrogen therapy.

Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh · The International journal of risk & safety in medicine · 2026

This narrative review examined the available molecular-hydrogen literature. Immediate transition to low-concentration (≤10% v/v H₂) inhalers is strongly recommended, as they provide effective concentration while eliminating life-threatening risks, ensuring patient safety without compromising clinical…

Primary topic
Respiratory and Lung Health
Delivery method
Other or not reported
Main limitation
Case-report evidence cannot establish causality or broad generalizability.
Study ID
DOI: 10.1177/09246479251414573
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Editorial NoticePreclinical animal evidenceAnimal studyOther or not reported

Six Hours of Hydrogen Gas Inhalation Has a Neuroprotective Effect Even in Piglets with Delayed Functional Recovery.

Eri Inoue, Shinji Nakamura, Yuichiro Sugiyama, Toui Tsuchiya, Yasuhiro Nakao, Tsutomu Mitsuie, Takayuki Yokota, Kosuke Sakamoto, Kota Inoue, Yinmon Htun, Aya Morimoto, Ken-Ichi Ohta, Hirosuke Morita, Sonoko Kondo, Kosuke Koyano, Aya Tanaka, Takanori Miki, Masaki Ueno, Takashi Kusaka · Developmental neuroscience · 2026

In an animal model, undamaged neuron numbers were significantly higher in the HI-H₂ group than in the HI group (p < 0.01), although RT-aEEG was not different. These preclinical findings add evidence supporting molecular…

Primary topic
Hydrogen Inhalation Research
Delivery method
Other or not reported
Study ID
DOI: 10.1159/000546831
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Laboratory or cellular evidenceLaboratory StudyOther or not reported

Nanoquadruplex-driven hydrogen therapy: NIR-controlled release for targeted cancer ferroptosis.

Chunxue Dai, Yingjiao He, Hongyan Lu, Xiaotong Feng, Naling Long, Qile Song, Yuwei Li, Yifan Wang, Lisandra L Martin, Cundong Fan, Dongdong Sun · Biomaterials · 2026

In The effect demonstrates that (PdH0.2)4Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro, high-efficiency hydrogen can be released from (PdH0.2)4Se, activated by near infrared irradiation (NIR), and…

Primary topic
Cancer and Supportive Oncology Research
Delivery method
Other or not reported
Main limitation
Preclinical animal findings may not translate directly to human outcomes.
Study ID
DOI: 10.1016/j.biomaterials.2025.123635
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Preclinical animal evidenceAnimal studyOther or not reported

Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.

Zhenkui Wang, Wei Feng, Jie Zhou, Lei Huang, Chuanfeng Fang, Jiarong Yuan, Hongsheng Chen, Li Xue · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026

In SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. The authors linked these findings to activation of the PINK1/Parkin…

Primary topic
Diabetes and Metabolic Health
Delivery method
Other or not reported
Study ID
DOI: 10.1016/j.jstrokecerebrovasdis.2026.108645
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Preclinical animal evidenceAnimal studyOther or not reported

Neuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.

Chaodeng Mo, Johny Bajgai, Md Habibur Rahman, Hui Ma, Thu Thao Pham, Haiyang Zhang, Buchan Cao, Eun-Sook Jeong, Cheol-Su Kim, Kyu-Jae Lee · Antioxidants (Basel, Switzerland) · 2026

In the hippocampus, H₂ upregulated nuclear factor erythroid 2-related factor 2 (NRF2), attenuated nuclear factor kappa B (NF-κB) activation, reduced the BAX/BCL-2 ratio, preserved neuronal nuclei (NEUN) expression, and decreased hippocampal Aβ42 burden. These…

Primary topic
Cancer and Supportive Oncology Research
Sample size
Not reported in abstract
Delivery method
Other or not reported
Main limitation
Preclinical mouse findings may not translate directly to people with Alzheimer’s disease, and the…
Study ID
DOI: 10.3390/antiox15030404
View Study Full Text
Editorial NoticeReview or synthesisNarrative reviewOther or not reported

New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment.

Mingkang Shi, Yu Duan, Jiawen Sun, Mengyao Li, Yaxin Wu, Wenbo Zhao, Chun Mao · Biomaterials science · 2026

This narrative review examined the available molecular-hydrogen literature. Hydrogen-synergistic diagnostic and therapeutic nanoplatforms (HSDT-NPs), a novel type of tool for tumor treatment, integrate hydrogen therapy with various tumor diagnostic and therapeutic strategies, significantly enhancing…

Primary topic
Cancer and Supportive Oncology Research
Delivery method
Other or not reported
Study ID
DOI: 10.1039/d5bm01802a
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Other source-grounded researchOther ResearchOther or not reported

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S-Nitrosylation of MEK1.

Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao · Plant biotechnology journal · 2026

Finally, S-nitrosylation of MEK1 increased its interaction with GSNOR, and H₂ further promoted this interaction under salt stress. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general…

Primary topic
Plant and Agricultural Research
Delivery method
Other or not reported
Main limitation
The abstract alone may not report all methodological limitations; full-text review is required.
Study ID
DOI: 10.1111/pbi.70585
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Other source-grounded researchOther Researchhydrogen-rich water

Effects of Hydrogen-Rich Water on Juvenile Largemouth Bass (Micropterus salmoides) Under Acute Low-Temperature Stress.

Qianqian Xu, Haolin Wang, Xue Chen, Long Chen, Paini Xin, Hua Liu, Ying Yang · Antioxidants (Basel, Switzerland) · 2026

Showed that after 30 days of HRW rearing, the final body weight (FBW), specific growth rate (SGR), and condition factor (CF) of the H1 group were significantly increased, while the H3 group only increased…

Primary topic
Gastrointestinal Health
Delivery method
hydrogen-rich water
Main limitation
The intervention or follow-up period appears relatively short.
Study ID
DOI: 10.3390/antiox15060742
View Study Full Text
Showing 1–10 of 1,661 studies