Nanoquadruplex-driven hydrogen therapy: NIR-controlled release for targeted cancer ferroptosis.
Chunxue Dai, Yingjiao He, Hongyan Lu, Xiaotong Feng, Naling Long, Qile Song, Yuwei Li, Yifan Wang, Lisandra L Martin, Cundong Fan, Dongdong Sun · Biomaterials · 2026
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In The effect demonstrates that (PdH0.2)4Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro, high-efficiency hydrogen can be released from (PdH0.2)4Se, activated by near infrared irradiation (NIR), and combines with available selenium (Se) to produce highly toxic hydrogen selenide (H2Se), which in turn unbalances the GSH/GSSG ratio and induces ROS overproduction. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in The effect demonstrates that (PdH0.2)4Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro. High-efficiency hydrogen can be released from (PdH0.2)4Se, activated by near infrared irradiation (NIR), and combines with available selenium (Se) to produce highly toxic hydrogen selenide (H2Se), which in turn unbalances the GSH/GSSG ratio and induces ROS overproduction.
What the Researchers Studied
The researchers studied The effect demonstrates that (PdH0.2)4Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro. The study used a in vitro cell-culture laboratory experiment.
What Effects Did Molecular Hydrogen Have?
High-efficiency hydrogen can be released from (PdH0.2)4Se, activated by near infrared irradiation (NIR), and combines with available selenium (Se) to produce highly toxic hydrogen selenide (H2Se), which in turn unbalances the GSH/GSSG ratio and induces ROS overproduction. Thus together, the findings support the rational design of an effective hydrogen storage (PdH0.2)4Se nanoquadruplex with NIR-controlled release causing an unbalance of cellular GSH/GSSG and inducing cancer ferroptosis could be a highly efficient strategy for hydrogen-mediated cancer therapy.
Why These Findings Matter
These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
How Strong Is This Evidence?
This is laboratory evidence from a in vitro cell-culture laboratory experiment. It is most informative for the biological mechanisms, cellular responses, or biochemical outcomes directly measured.
Technical Study Details
H2HUBB classifies this publication as laboratory study with laboratory or cellular evidence. The research population or model was The effect demonstrates that (PdH0.2)4Se irradiated by NIR significantly inhibits cancer cell proliferation, migration, invasion and angiogenesis in vitro. The study used a in vitro cell-culture laboratory experiment.
Limitations and Safety
Reported limitations: However, the limitations of effective hydrogen storage and release have hindered its development and application for hydrogen therapy.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.