1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats
Sato Tsunehisa, Mimuro Soichiro, Katoh Takasumi, Kurita Tadayoshi, Truong Sang Kien, Kobayashi Kensuke, Makino Hiroshi, Doi Matsuyuki, Nakajima Yoshiki · Journal of Anesthesia · 2020
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats” is organized in H2HUBB under the research focus hydrogen inhalation blood pressure study 2020. The publication is cited as Sato Tsunehisa, Mimuro Soichiro, Katoh Takasumi, Kurita Tadayoshi, Truong Sang Kien, Kobayashi Kensuke, Makino Hiroshi, Doi Matsuyuki, Nakajima Yoshiki, Journal of Anesthesia, 2020. This animal study examined 1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of 1.2% H gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock. Therapeutic efficacy might vary depending on the concentration. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation blood pressure study 2020 overview
Hydrogen gas (H) inhalation improved the survival rate of hemorrhagic shock. However, its mechanisms are unknown. We hypothesized that H protected the endothelial glycocalyx… Animal research can identify biological effects and support future investigation, but it cannot by itself establish safety or effectiveness in humans.
Study design and hydrogen intervention
Publication type: Animal study. Evidence type: Preclinical animal evidence. Research model or population: Rat model. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen inhalation.
Reported findings and scientific interpretation
For this hydrogen inhalation blood pressure study 2020, the study record reports the following: The abstract reports: Inhalation of 1.2% H gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock. Therapeutic efficacy might vary depending on the concentration.
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Preclinical animal findings may not translate directly to human outcomes.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.