Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest.
Astapenko D, Hyspler R, Ticha A, Tomasova A, Navratil P, Zrzavecky M, Byreddy B, Sedlacek P, Radochova V, Skulec R, Hahn RG, Lehmann C, Malbrain MLNG, Cerny V · Clinical hemorheology and microcirculation · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest.” is organized in H2HUBB under the research focus hydrogen inhalation blood pressure study 2023 astapenko. The publication is cited as Astapenko D, Hyspler R, Ticha A, Tomasova A, Navratil P, Zrzavecky M, Byreddy B, Sedlacek P, Radochova V, Skulec R, Hahn RG, Lehmann C, Malbrain MLNG, Cerny V, Clinical hemorheology and microcirculation, 2023. This animal study examined Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation. The abstract reports: In pigs, hydrogen gas inhalation during CPR and post-resuscitation care was associated with less pronounced metabolic acidosis compared to controls. However, we could not…. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation blood pressure study 2023 astapenko overview
Hydrogen is a potent antioxidant agent that can easily be administered by inhalation. The aim of the study was to evaluate whether hydrogen protects… Animal research can identify biological effects and support future investigation, but it cannot by itself establish safety or effectiveness in humans.
Study design and hydrogen intervention
Publication type: Animal study. Evidence type: Preclinical animal evidence. Research model or population: Porcine model. Blinding: Unknown. Control status: Control group reported.
Delivery method: Hydrogen inhalation.
Reported findings and scientific interpretation
For this hydrogen inhalation blood pressure study 2023 astapenko, the study record reports the following: The abstract reports: In pigs, hydrogen gas inhalation during CPR and post-resuscitation care was associated with less pronounced metabolic acidosis compared to controls. However, we could not…
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Preclinical animal findings may not translate directly to human outcomes.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.