Hydrogen’s Feasibility and Safety as a Therapy in Extracorporeal Cardiopulmonary Resuscitation (Hydrogen-FAST): study protocol for a trial of inhaled hydrogen gas as an adjunctive therapy in refractory cardiac arrest.
Victoria Habet; Tysen DeWaard; Krislyn M Boggs; Alix Fetch; Bao Nguyen Puente; Lynn A Sleeper; John N Kheir · Trials · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB PLAIN-LANGUAGE TAKEAWAY
This record describes a planned hydrogen study; no treatment result is available yet.
Hydrogen inhalation cardiac arrest study 2025: what the findings mean
This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival for patients experiencing refractory cardiac arrest but is often associated with severe ischemia-reperfusion injury (damage that can occur when blood flow returns after a period of low oxygen) (IRI). Hydrogen gas (H) has demonstrated promising preclinical efficacy in reducing IRI. The Hydrogen-FAST trial investigates the feasibility and safety of inhaled hydrogen gas as an adjunctive therapy during ECPR in patients with congenital heart disease (CHD).
Publication: Victoria Habet; Tysen DeWaard; Krislyn M Boggs; Alix Fetch; Bao Nguyen Puente; Lynn A Sleeper; John N Kheir, Trials, 2025.
What the researchers studied
The researchers examined how hydrogen inhalation related to cardiac arrest. The available structured record did not clearly identify one primary outcome, so the original source should be checked for the complete endpoint definitions.
What effects did molecular hydrogen have?
No treatment effects have been reported yet. This publication describes a planned study rather than completed results.
Why these findings matter
This publication describes how a study is planned. It cannot yet support a conclusion about hydrogen’s therapeutic potential because completed results have not been reported.
How strong is this evidence?
This is a study protocol, so no completed outcome evidence is available yet. Randomization: Not applicable. Comparison or control: Not applicable. Blinding: Not applicable.
Technical study details
- Publication type: Study protocol
- Evidence type: Protocol or ongoing research
- Research model or population: Human participants
- Randomized: Not applicable
- Blinding: Not applicable
- Control or comparison: Not applicable
- Hydrogen method: Hydrogen inhalation
Limitations and safety
Important limitations: This protocol does not report completed study outcomes.
Safety information: The available structured record did not provide a separate safety conclusion. This does not mean adverse events were assessed or absent.
Original study and H2HUBB research context
This page explains a published research record and does not turn one study into a medical recommendation. Read the original scientific source for the complete methods, statistics, and author conclusions. Compare this result with related evidence in the H2HUBB Molecular Hydrogen Research Library.