Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial
Tamura Tomoyoshi, Suzuki Masaru, Homma Koichiro, Sano Motoaki, Iizuka Ryoji, Narimiya Hiromichi, Tsuruta Ryosuke, Kaneda Kotaro, Fujita Motoki, Sasaki Junichi, Akasaka Osamu, Sawai Keisuke, Nozaki Makiko, Imai Hiroshi, Ishikura Ken, Ikejiri Kaoru, Kakihana Yasuyuki, Niiyama Shuhei, Futatsuki Takahiro, Honda Masahiro, Ikeda Yasuhiro, Oka Hideo, Yoshihara Hideaki, Onishi Hirokazu, Yamashita Susumu, Shimizu Koki, Sakurai Toshihiro, Yamada Shu, Fukami Hiroshi, Shime Nobuaki, Suzuki Kei, Kuroda Yasuhiro, Kawakita Kenya, Kimura Akio, Uemura Tatsuki, Takuma Kiyotsugu, Kanao Kunio, Yanagawa Youichi, Takeuchi Ikuto · eClinicalMedicine · 2023
Research-use notice
Independent study record
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The publication “Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial” is organized in H2HUBB under the research focus hydrogen inhalation cardiovascular health study 2023 tomoyoshi. The publication is cited as Tamura Tomoyoshi, Suzuki Masaru, Homma Koichiro, Sano Motoaki, Iizuka Ryoji, Narimiya Hiromichi, Tsuruta Ryosuke, Kaneda Kotaro, Fujita Motoki, Sasaki Junichi, Akasaka Osamu, Sawai Keisuke, Nozaki Makiko, Imai Hiroshi, Ishikura Ken, Ikejiri Kaoru, Kakihana Yasuyuki, Niiyama Shuhei, Futatsuki Takahiro, Honda Masahiro, Ikeda Yasuhiro, Oka Hideo, Yoshihara Hideaki, Onishi Hirokazu, Yamashita Susumu, Shimizu Koki, Sakurai Toshihiro, Yamada Shu, Fukami Hiroshi, Shime Nobuaki, Suzuki Kei, Kuroda Yasuhiro, Kawakita Kenya, Kimura Akio, Uemura Tatsuki, Takuma Kiyotsugu, Kanao Kunio, Yanagawa Youichi, Takeuchi Ikuto, eClinicalMedicine, 2023. This registered clinical trial examined Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial. The abstract describes Planned or registered research population; sample size 429; hydrogen delivered as hydrogen inhalation. The abstract reports: The trial was terminated prematurely because of the restrictions imposed on enrolment during the COVID-19 pandemic. Between February 1, 2017, and September 30, 2021,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation cardiovascular health study 2023 tomoyoshi overview
Inhaled molecular hydrogen gas (H) has been shown to improve outcomes in animal models of cardiac arrest (CA). H inhalation is safe and feasible… A protocol describes planned methods and does not provide completed outcome evidence.
Study design and hydrogen intervention
Publication type: Registered clinical trial. Evidence type: Protocol or ongoing research. Research model or population: Planned or registered research population. Sample size: 429. Randomized: Yes. Blinding: Double-blind. Control status: Placebo-controlled.
Delivery method: Hydrogen inhalation.
Reported findings and scientific interpretation
For this hydrogen inhalation cardiovascular health study 2023 tomoyoshi, the study record reports the following: The abstract reports: The trial was terminated prematurely because of the restrictions imposed on enrolment during the COVID-19 pandemic. Between February 1, 2017, and September 30, 2021,…
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.