Hydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with high-fat diet-induced non-alcoholic fatty liver disease.
Xue J, Zhao M, Liu Y, Jia X, Zhang X, Gu Q, Xie Y, Qin S, Liu B · European journal of pharmacology · 2023
Research-use notice
Independent study record
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The publication “Hydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with high-fat diet-induced non-alcoholic fatty liver disease.” is organized in H2HUBB under the research focus hydrogen inhalation gut microbiome study 2023. The publication is cited as Xue J, Zhao M, Liu Y, Jia X, Zhang X, Gu Q, Xie Y, Qin S, Liu B, European journal of pharmacology, 2023. This animal study examined Hydrogen inhalation ameliorates hepatic inflammation and modulates gut microbiota in rats with high-fat diet-induced non-alcoholic fatty liver disease. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation; reported duration 10 weeks. The abstract reports: Liver transcriptomic data suggested that H treatment significantly downregulated inflammatory response genes, and the lipopolysaccharide (LPS)/Toll-like receptor (TLR) 4/nuclear transcription factor kappa B (NF-κB)…. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation gut microbiome study 2023 overview
The present study was aimed to clarify the effects of 4% H inhalation on NAFLD and its mechanism of action. Animal research can identify biological effects and support future investigation, but it cannot by itself establish safety or effectiveness in humans.
Study design and hydrogen intervention
Publication type: Animal study. Evidence type: Preclinical animal evidence. Research model or population: Rat model. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen inhalation. Treatment duration: 10 weeks.
Reported findings and scientific interpretation
For this hydrogen inhalation gut microbiome study 2023, the study record reports the following: The abstract reports: Liver transcriptomic data suggested that H treatment significantly downregulated inflammatory response genes, and the lipopolysaccharide (LPS)/Toll-like receptor (TLR) 4/nuclear transcription factor kappa B (NF-κB)…
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Preclinical animal findings may not translate directly to human outcomes.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.