Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.
Cole AR, Sperotto F, DiNardo JA, Carlisle S, Rivkin MJ, Sleeper LA, Kheir JN · Critical care explorations · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.” is organized in H2HUBB under the research focus hydrogen inhalation hydrogen safety study 2021. The publication is cited as Cole AR, Sperotto F, DiNardo JA, Carlisle S, Rivkin MJ, Sleeper LA, Kheir JN, Critical care explorations, 2021. This uncontrolled human study examined Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of 2.4% hydrogen gas does not appear to cause clinically significant adverse effects in healthy adults. Although these data suggest that inhaled hydrogen…. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation hydrogen safety study 2021 overview
The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study. Because this is human clinical evidence, relevance depends on participant selection, controls, sample size, treatment duration, adherence, outcome measures, and replication.
Study design and hydrogen intervention
Publication type: Uncontrolled human study. Evidence type: Human clinical evidence. Research model or population: Human participants. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen inhalation. Hydrogen flow rate: 15 L/min. Dose or treatment amount: 15 L.
Reported findings and scientific interpretation
For this hydrogen inhalation hydrogen safety study 2021, the study record reports the following: The abstract reports: Inhalation of 2.4% hydrogen gas does not appear to cause clinically significant adverse effects in healthy adults. Although these data suggest that inhaled hydrogen…
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety: The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.