Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A · American journal of physiology. Lung cellular and molecular physiology · 2013
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.” is organized in H2HUBB under the research focus hydrogen inhalation oxidative stress study 2013 kawamura. The publication is cited as Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A, American journal of physiology. Lung cellular and molecular physiology, 2013. This uncontrolled human study examined Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme oxygenase (HO)-1. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen inhalation oxidative stress study 2013 kawamura overview
To determine whether hydrogen could reduce hyperoxic lung injury and investigate the underlying mechanisms, we randomly assigned rats to four experimental groups and administered… Because this is human clinical evidence, relevance depends on participant selection, controls, sample size, treatment duration, adherence, outcome measures, and replication.
Study design and hydrogen intervention
Publication type: Uncontrolled human study. Evidence type: Human clinical evidence. Research model or population: Human participants. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen inhalation.
Reported findings and scientific interpretation
For this hydrogen inhalation oxidative stress study 2013 kawamura, the study record reports the following: The abstract reports: We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and induced heme oxygenase (HO)-1.
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.