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Human clinical evidenceUncontrolled human studyHydrogen-rich saline

Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity.

Sun Q, Cai J, Zhou J, Tao H, Zhang JH, Zhang W, Sun XJ · Critical care medicine · 2011

Research-use notice

Independent study record

Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

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Primary topic Inflammation and Immune Regulation
Evidence type Human clinical evidence
Publication type Uncontrolled human study
Hydrogen method Hydrogen-rich saline
hydrogen-rich saline inflammation immune study 2011 research summary

The publication “Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity.” is organized in H2HUBB under the research focus hydrogen-rich saline inflammation immune study 2011. The publication is cited as Sun Q, Cai J, Zhou J, Tao H, Zhang JH, Zhang W, Sun XJ, Critical care medicine, 2011. This uncontrolled human study examined Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 40 min. The abstract reports: This observation demonstrated that hydrogen-rich saline peritoneal injection improves histologic and functional assessment in a rat model of CO encephalopathy. Hydrogen saline has potentials…. This is an automated editorial draft based on the abstract and requires source review before publication.

Hydrogen-rich saline inflammation immune study 2011 overview

We investigated the feasibility and efficacy of hydrogen-rich saline therapy on delayed neurologic sequelae in a rat model of severe acute carbon monoxide (CO)… Because this is human clinical evidence, relevance depends on participant selection, controls, sample size, treatment duration, adherence, outcome measures, and replication.

Study design and hydrogen intervention

Publication type: Uncontrolled human study. Evidence type: Human clinical evidence. Research model or population: Human participants. Blinding: Unknown. Control status: Unknown.

Delivery method: Hydrogen-rich saline. Hydrogen concentration: 3000 ppm. Dose or treatment amount: 10 mL. Treatment duration: 40 min.

Reported findings and scientific interpretation

For this hydrogen-rich saline inflammation immune study 2011, the study record reports the following: The abstract reports: This observation demonstrated that hydrogen-rich saline peritoneal injection improves histologic and functional assessment in a rat model of CO encephalopathy. Hydrogen saline has potentials…

These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.

How this research record was prepared

H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.

Limitations, safety, and original source

Limitations: The abstract alone may not report all methodological limitations; full-text review is required.

Safety: The abstract did not provide detailed safety or adverse-event information.

This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.