Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.

The publication “Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.” is organized in H2HUBB under the research focus hydrogen neurological study 2022 hirano. The publication is cited as Hirano M, Sugai K, Fujisawa M, Kobayashi E, Katsumata Y, Hakamata Y, Sano M, PloS one, 2022. This in vitro or cellular study examined Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Intraperitoneal administration of H2-rich saline resulted in large increases in H2 concentration in the IVC ranging from 0.00183 mg/L (0.114%) to 0.00725 mg/L (0.453%). This is an automated editorial draft based on the abstract and requires source review before publication.

Hydrogen neurological study 2022 hirano overview

In this study, we investigated whether intraperitoneal administration of saline containing H2 inhibits neuronal cell death caused by cerebral ischemia and measured the concentration… Laboratory and cellular research can clarify mechanisms, but it does not establish clinical benefit or reproduce the complexity of a living human system.

Study design and hydrogen intervention

Publication type: In vitro or cellular study. Evidence type: Laboratory or cellular evidence. Research model or population: Cell culture / in vitro model. Blinding: Unknown. Control status: Unknown.

Delivery method: Hydrogen-rich saline. Hydrogen concentration: 0.00183 mg/L. Dose or treatment amount: 0.00183 mg.

Reported findings and scientific interpretation

For this hydrogen neurological study 2022 hirano, the study record reports the following: The abstract reports: Intraperitoneal administration of H2-rich saline resulted in large increases in H2 concentration in the IVC ranging from 0.00183 mg/L (0.114%) to 0.00725 mg/L (0.453%).

These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.

How this research record was prepared

H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.

Limitations, safety, and original source

Limitations: Laboratory findings may not translate directly to living organisms or clinical outcomes.

Safety: The abstract did not provide detailed safety or adverse-event information.

This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.