Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress.

The publication “Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress.” is organized in H2HUBB under the research focus hydrogen-rich saline oxidative stress study 2013. The publication is cited as Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, Yuan H, Yu W, The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2013. This animal study examined Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. The abstract describes Rat model; sample size 10; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of…. This is an automated editorial draft based on the abstract and requires source review before publication.

Hydrogen-rich saline oxidative stress study 2013 overview

Reactive oxygen species (ROS) are often associated with persistent pains such as neuropathic and inflammatory pain. Hydrogen gas can reduce ROS and alleviate cerebral,… Animal research can identify biological effects and support future investigation, but it cannot by itself establish safety or effectiveness in humans.

Study design and hydrogen intervention

Publication type: Animal study. Evidence type: Preclinical animal evidence. Research model or population: Rat model. Sample size: 10. Blinding: Unknown. Control status: Unknown.

Delivery method: Hydrogen-rich saline.

Reported findings and scientific interpretation

For this hydrogen-rich saline oxidative stress study 2013, the study record reports the following: The abstract reports: Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of…

These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.

How this research record was prepared

H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.

Limitations, safety, and original source

Limitations: Preclinical animal findings may not translate directly to human outcomes.

Safety: The abstract did not provide detailed safety or adverse-event information.

This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.