Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers.
Nikola Todorovic, Dragana Zanini, Valdemar Stajer, Darinka Korovljev, Jelena Ostojic, Sergej M Ostojic · Food science & nutrition · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 16 apparently healthy, young participants, both HRW and caffeine significantly increased the choline-to-creatine ratio in several brain regions (frontal white and gray matter), while HRW and the combination intervention also affected brain metabolism in the paracentral brain. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes in healthy men.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in 16 apparently healthy, young participants. Both HRW and caffeine significantly increased the choline-to-creatine ratio in several brain regions (frontal white and gray matter), while HRW and the combination intervention also affected brain metabolism in the paracentral brain.
What the Researchers Studied
The researchers studied 16 apparently healthy, young participants. The study used a randomized, crossover human clinical trial. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Both HRW and caffeine significantly increased the choline-to-creatine ratio in several brain regions (frontal white and gray matter), while HRW and the combination intervention also affected brain metabolism in the paracentral brain.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence sleep-related outcomes in healthy men and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, crossover human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 16 apparently healthy, young participants. The reported sample size was 8. The study used a randomized, crossover human clinical trial. The hydrogen delivery method was hydrogen-rich water. The reported hydrogen concentration was 8 mg/L H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.