Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function
Ishibashi Toru, Sakai Takaaki, Sato Bunpei, Hara Koji, Hara Yuichi, Naritomi Yuji, Koyanagi Samon, Hara Hiroshi, Nagao Tetsuhiko · Vascular Health and Risk Management · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.

The publication “Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function” is organized in H2HUBB under the research focus hydrogen water blood pressure study 2014. The publication is cited as Ishibashi Toru, Sakai Takaaki, Sato Bunpei, Hara Koji, Hara Yuichi, Naritomi Yuji, Koyanagi Samon, Hara Hiroshi, Nagao Tetsuhiko, Vascular Health and Risk Management, 2014. This uncontrolled human study examined Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: H2 may protect the vasculature from shear stress-derived detrimental ROS, such as the hydroxyl radical, by maintaining the nitric oxide-mediated vasomotor response. This is an automated editorial draft based on the abstract and requires source review before publication.
Hydrogen water blood pressure study 2014 overview
To assess the influence of the hydroxyl radical on the endothelium and to confirm that a gaseous antioxidant, H2, can be a useful modulator… Because this is human clinical evidence, relevance depends on participant selection, controls, sample size, treatment duration, adherence, outcome measures, and replication.
Study design and hydrogen intervention
Publication type: Uncontrolled human study. Evidence type: Human clinical evidence. Research model or population: Human participants. Blinding: Unknown. Control status: Unknown.
Delivery method: Hydrogen water. Hydrogen concentration: 7 ppm. Dose or treatment amount: 3.5 mg.
Reported findings and scientific interpretation
For this hydrogen water blood pressure study 2014, the study record reports the following: The abstract reports: H2 may protect the vasculature from shear stress-derived detrimental ROS, such as the hydroxyl radical, by maintaining the nitric oxide-mediated vasomotor response.
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.