Randomized, double‐blind, multicenter trial of hydrogen water for Parkinson’s disease
A. Yoritaka, C. Ohtsuka, T. Maeda, M. Hirayama, T. Abe, Hirohisa Watanabe, H. Saiki, G. Oyama, J. Fukae, Y. Shimo, T. Hatano, S. Kawajiri, Y. Okuma, Y. Machida, H. Miwa, C. Suzuki, A. Kazama, M. Tomiyama, T. Kihara, M. Hirasawa, H. Shimura, E. Oda, Mikako Ito, K. Ohno, N. Hattori · Movement Disorders · 2018
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Independent study record
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H2HUBB TAKEAWAY
Randomized, double‐blind, multicenter trial of hydrogen water for Parkinson's disease A previous randomized, doubleblind study showed that drinking 1,000 mL of H₂ water per day for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) scores of patients with PD and treated with levodopa. The researchers conducted a longer and larger scale H₂ water trial that also included patients who were not treated with levodopa.
What the Researchers Studied
The study examined 178 participants with PD (93 women and 85 men.
How Molecular Hydrogen Was Used
A previous randomized, doubleblind study showed that drinking 1,000 mL of H₂ water per day for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) scores of patients with PD and treated with levodopa. The researchers conducted a longer and larger scale H₂ water trial that also included patients who were not treated with levodopa.
What the Researchers Found
A previous randomized, doubleblind study showed that drinking 1,000 mL of H₂ water per day for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) scores of patients with PD and treated with levodopa. There were no significant differences in the change in the total UPDRS score from baseline to the 72nd week between the H₂-water group (1.6 ± 14.0 [mean ± standard deviation]) and the placebo water group (0.8 ± 9.6; t test, P =.939; analysis of variance, P =.538; Table 1).
H₂ Mechanisms / Biological Findings
Molecular hydrogen (H₂) water has been shown to reduce oxidative stress and dopaminergic neuronal cell loss in a PD model.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.