Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota.
Yi-Tong Lin, Qing-Qing Shi, Lei Zhang, Cai-Ping Yue, Zhi-Jun He, Xue-Xia Li, Qian-Jun He, Qiong Liu, Xiu-Bo Du · Neural regeneration research · 2022
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined mice.
How Molecular Hydrogen Was Used
In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months.
What the Researchers Found
Hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. Hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions.
H₂ Mechanisms / Biological Findings
Hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions.
Authors’ Conclusion
The authors concluded that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease.
Limitations Reported by the Authors
Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice.