Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes.
Liu C, Kurokawa R, Fujino M, Hirano S, Sato B, Li XK · Scientific reports · 2014
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Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB PLAIN-LANGUAGE TAKEAWAY
Molecular hydrogen produced a favorable primary result in this animal study, supporting further research into its potential for safety, dosage, and pharmacokinetics.
Injected hydrogen hydrogen safety study 2014: what the findings mean
This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. This animal study examined Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes. The abstract describes Rat model; hydrogen delivered as injected or infused hydrogen. Following inhalation of hydrogen gas, the hydrogen concentration was found to be significantly increased at 30 minutes and maintained the same level thereafter.
Publication: Liu C, Kurokawa R, Fujino M, Hirano S, Sato B, Li XK, Scientific reports, 2014.
What the researchers studied
The researchers examined how injected or infused hydrogen related to safety, dosage, and pharmacokinetics. The available structured record did not clearly identify one primary outcome, so the original source should be checked for the complete endpoint definitions.
What effects did molecular hydrogen have?
Observed hydrogen effects: Following inhalation of hydrogen gas, the hydrogen concentration was found to be significantly increased at 30 minutes and maintained the same level thereafter. Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury (damage that can occur when blood flow returns after a period of low oxygen) as well as inflammatory and neurological disease.
Why these findings matter
The result supports the biological and therapeutic potential of injected or infused hydrogen for safety, dosage, and pharmacokinetics. It shows that hydrogen affected meaningful outcomes in an animal model, but it does not prove that the same benefit will occur in people.
How strong is this evidence?
This is preclinical animal evidence. It can show biological effects in a whole living system, but human effectiveness and dosing still require clinical trials.
Technical study details
- Publication type: Animal study
- Evidence type: Preclinical animal evidence
- Research model or population: Rat model
- Hydrogen method: Injected or infused hydrogen
Limitations and safety
Important limitations: Preclinical animal findings may not translate directly to human outcomes.
Safety information: The abstract did not provide detailed safety or adverse-event information.
Original study and H2HUBB research context
This page explains a published research record and does not turn one study into a medical recommendation. Read the original scientific source for the complete methods, statistics, and author conclusions. Compare this result with related evidence in the H2HUBB Molecular Hydrogen Research Library.