Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
Nishimaki Kiyomi, Asada Takashi, Ohsawa Ikuroh, Nakajima Etsuko, Ikejima Chiaki, Yokota Takashi, Kamimura Naomi, Ohta Shigeo · Current Alzheimer Research · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment” is organized in H2HUBB under the research focus molecular hydrogen cognitive health study 2018. The publication is cited as Nishimaki Kiyomi, Asada Takashi, Ohsawa Ikuroh, Nakajima Etsuko, Ikejima Chiaki, Yokota Takashi, Kamimura Naomi, Ohta Shigeo, Current Alzheimer Research, 2018. This randomized controlled trial examined Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. The abstract describes Human participants; sample size 73. The abstract reports: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI. This is an automated editorial draft based on the abstract and requires source review before publication.
Molecular hydrogen cognitive health study 2018 overview
We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. Because this is human clinical evidence, relevance depends on participant selection, controls, sample size, treatment duration, adherence, outcome measures, and replication.
Study design and hydrogen intervention
Publication type: Randomized controlled trial. Evidence type: Human clinical evidence. Research model or population: Human participants. Sample size: 73. Randomized: Yes. Blinding: Double-blind. Control status: Placebo-controlled.
Delivery method: Other or not reported. Dose or treatment amount: 300 mL.
Reported findings and scientific interpretation
For this molecular hydrogen cognitive health study 2018, the study record reports the following: The abstract reports: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: The abstract alone may not report all methodological limitations; full-text review is required.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.