Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics.
Dong A, Yu Y, Wang Y, Li C, Chen H, Bian Y, Zhang P, Zhao Y, Yu Y, Xie K · International immunopharmacology · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics.” is organized in H2HUBB under the research focus molecular hydrogen mitochondrial function study 2018 dong. The publication is cited as Dong A, Yu Y, Wang Y, Li C, Chen H, Bian Y, Zhang P, Zhao Y, Yu Y, Xie K, International immunopharmacology, 2018. This animal study examined Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics. The abstract describes Mouse model. The abstract reports: Therapy with 2% H increased PaO/FiO ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1…. This is an automated editorial draft based on the abstract and requires source review before publication.
Molecular hydrogen mitochondrial function study 2018 dong overview
Lungs are one of the most common target organs of sepsis [1]. Hydrogen gas (H), which has selective anti-oxidative effects, can be effectively used… Animal research can identify biological effects and support future investigation, but it cannot by itself establish safety or effectiveness in humans.
Study design and hydrogen intervention
Publication type: Animal study. Evidence type: Preclinical animal evidence. Research model or population: Mouse model. Randomized: Yes. Blinding: Unknown. Control status: Unknown.
Delivery method: Other or not reported.
Reported findings and scientific interpretation
For this molecular hydrogen mitochondrial function study 2018 dong, the study record reports the following: The abstract reports: Therapy with 2% H increased PaO/FiO ratios, MMP and ATP levels, RCR, complex I activity and MFN2 expression but decreased histological score and Drp1…
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Preclinical animal findings may not translate directly to human outcomes.
Safety: The abstract did not provide detailed safety or adverse-event information.
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.