Hydrogen protects auditory hair cells from cisplatin-induced free radicals.
Kikkawa YS, Nakagawa T, Taniguchi M, Ito J · Neuroscience letters · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
The publication “Hydrogen protects auditory hair cells from cisplatin-induced free radicals.” is organized in H2HUBB under the research focus molecular hydrogen oxidative stress study 2014 kikkawa. The publication is cited as Kikkawa YS, Nakagawa T, Taniguchi M, Ito J, Neuroscience letters, 2014. This in vitro or cellular study examined Hydrogen protects auditory hair cells from cisplatin-induced free radicals. The abstract describes Cell culture / in vitro model. The abstract reports: Additionally, hydroxyphenyl fluorescein (HPF) staining of the spiral ganglion showed that formation of hydroxyl radicals was successfully reduced in hydrogen-treated cochleae. This is an automated editorial draft based on the abstract and requires source review before publication.
Molecular hydrogen oxidative stress study 2014 kikkawa overview
The purpose of this study was to evaluate the potential of molecular hydrogen to protect cochleae against cisplatin. Laboratory and cellular research can clarify mechanisms, but it does not establish clinical benefit or reproduce the complexity of a living human system.
Study design and hydrogen intervention
Publication type: In vitro or cellular study. Evidence type: Laboratory or cellular evidence. Research model or population: Cell culture / in vitro model. Blinding: Unknown. Control status: Unknown.
Delivery method: Other or not reported.
Reported findings and scientific interpretation
For this molecular hydrogen oxidative stress study 2014 kikkawa, the study record reports the following: The abstract reports: Additionally, hydroxyphenyl fluorescein (HPF) staining of the spiral ganglion showed that formation of hydroxyl radicals was successfully reduced in hydrogen-treated cochleae.
These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.
How this research record was prepared
H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.
Limitations, safety, and original source
Limitations: Laboratory findings may not translate directly to living organisms or clinical outcomes.
However, its maximum dose is often limited by severe ototoxicity.
Safety: These data suggest that molecular hydrogen can protect auditory tissues against cisplatin toxicity, thus providing an additional strategy to protect against drug-induced inner ear…
This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.