Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress

The publication “Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress” is organized in H2HUBB under the research focus molecular hydrogen oxidative stress study 2017. The publication is cited as Wu Ching-Ying, Hsu Wen-Li, Tsai Ming-Hsien, Liang Jui-Lin, Lu Jian-He, Yen Chia-Jung, Yu Hsin-Su, Noda Mami, Lu Chi-Yu, Chen Chu-Huang, Yan Shian-Jang, Yoshioka Tohru, Scientific Reports, 2017. This in vitro or cellular study examined Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. The abstract describes Keratinocyte model. The abstract reports: In the present study, HO dose-dependently impaired the adenosine triphosphate (ATP)-induced Ca response, which was partially protected via co-treatment with β-mercaptoethanol, resulting in reduced…. This is an automated editorial draft based on the abstract and requires source review before publication.

Molecular hydrogen oxidative stress study 2017 overview

The main outcome was not fully reported in the available structured record and should be checked against the original source. Laboratory and cellular research can clarify mechanisms, but it does not establish clinical benefit or reproduce the complexity of a living human system.

Study design and hydrogen intervention

Publication type: In vitro or cellular study. Evidence type: Laboratory or cellular evidence. Research model or population: Keratinocyte model. Blinding: Unknown. Control status: Unknown.

Delivery method: Other or not reported.

Reported findings and scientific interpretation

For this molecular hydrogen oxidative stress study 2017, the study record reports the following: The abstract reports: In the present study, HO dose-dependently impaired the adenosine triphosphate (ATP)-induced Ca response, which was partially protected via co-treatment with β-mercaptoethanol, resulting in reduced…

These findings should be interpreted as one piece of evidence rather than as a stand-alone medical conclusion. Results can be influenced by the research model, study design, treatment protocol, sample size, outcome selection, statistical methods, and whether the findings have been independently reproduced.

How this research record was prepared

H2HUBB organizes bibliographic details, study design information, intervention data, outcomes, limitations, and safety notes from the available scientific source. Automated classification supports database organization, but it does not replace critical reading of the complete paper. Source identifiers, evidence labels, and delivery-method fields are retained so readers can verify the record and compare it with related publications. A missing field means the information was unavailable or not reported in the structured source; it should not be treated as a negative finding.

Limitations, safety, and original source

Limitations: Laboratory findings may not translate directly to living organisms or clinical outcomes.

Safety: The abstract did not provide detailed safety or adverse-event information.

This H2HUBB page is an educational research record, not medical advice. Review the original scientific source for the complete methods and results. Continue exploring the H2HUBB Molecular Hydrogen Research Library to compare evidence types, delivery methods, and related topics.