Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs.
Genki Ichihara, Yoshinori Katsumata, Hidenori Moriyama, Hiroki Kitakata, Akeo Hirai, Mizuki Momoi, Seien Ko, Yoshiki Shinya, Kenichiro Kinouchi, Eiji Kobayashi, Motoaki Sano · Heliyon · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, after infusion of the H₂-rich glucose solution, H₂ concentration in the portal vein peaked at 0.05 mg/L and remained at more than 0.016 mg/L (H₂ saturation level, 1%) after 1 h; it also increased after infusion of H₂-free glucose solution but remained below 0.001 mg/L (H₂ saturation level, 0.06%). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water was evaluated in this publication and summarizes the source-grounded findings below. After infusion of the H₂-rich glucose solution, H₂ concentration in the portal vein peaked at 0.05 mg/L and remained at more than 0.016 mg/L (H₂ saturation level, 1%) after 1 h; it also increased after infusion of H₂-free glucose solution but remained below 0.001 mg/L (H₂ saturation level, 0.06%).
What the Researchers Studied
The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
After infusion of the H₂-rich glucose solution, H₂ concentration in the portal vein peaked at 0.05 mg/L and remained at more than 0.016 mg/L (H₂ saturation level, 1%) after 1 h; it also increased after infusion of H₂-free glucose solution but remained below 0.001 mg/L (H₂ saturation level, 0.06%). The authors concluded that, drinking highly concentrated H₂-rich solution within a short time is a good way to increase H₂ concentration in portal blood and supply H₂ to the liver.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The reported sample size was 4. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The reported hydrogen concentration was 0.05 mg/L H₂.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.