Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.
Alexis R Cole, Francesca Sperotto, James A DiNardo, Stephanie Carlisle, Michael J Rivkin, Lynn A Sleeper, John N Kheir · Critical care explorations · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 healthy participants, although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety. These findings add human evidence supporting molecular hydrogen's therapeutic potential for stroke recovery.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 8 healthy participants. Although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety.
What the Researchers Studied
The researchers studied 8 healthy participants. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
2.4% inhaled H₂ concentration. Although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for stroke recovery and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 healthy participants. The reported sample size was 8. The study used a human clinical study. The hydrogen delivery method was inhaled hydrogen gas. The reported hydrogen concentration was 2.4% inhaled H₂ concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.