Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults.
Alexis R Cole, Francesca Sperotto, James A DiNardo, Stephanie Carlisle, Michael J Rivkin, Lynn A Sleeper, John N Kheir · Critical care explorations · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 8 healthy participants, sEROLOGICAL TESTING: A predefined battery of laboratory testing was analyzed prior to and within 2 hours following the completion of H₂ exposure. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in 8 healthy participants. SEROLOGICAL TESTING: A predefined battery of laboratory testing was analyzed prior to and within 2 hours following the completion of H₂ exposure.
What the Researchers Studied
The researchers studied 8 healthy participants. The study used a human clinical study.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 2.4% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 2.4% source-reported H₂ gas concentration; via nasal cannula; H2HUBB estimated inhaled H₂ concentration: approximately 50.0–66.7% under standard resting adult assumptions from the source-reported 15 L/min pure-H₂ flow; reported treatment duration: 4 hr. SEROLOGICAL TESTING: A predefined battery of laboratory testing was analyzed prior to and within 2 hours following the completion of H₂ exposure. The authors concluded that although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety.
Why These Findings Matter
This publication adds useful evidence about where molecular hydrogen did and did not change the measured outcomes, helping define the larger therapeutic evidence base.
How Strong Is This Evidence?
This is human clinical evidence from a human clinical study. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 8 healthy participants. The reported sample size was 8. The study used a human clinical study. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 2.4% source-reported H₂ gas concentration. H2HUBB estimated inhaled H₂ concentration: approximately 50.0–66.7% under standard resting adult assumptions from the source-reported 15 L/min pure-H₂ flow. This is a calculated estimate, not a directly measured concentration, and actual inhaled H₂ varies with breathing pattern, ventilation, cannula capture, and gas losses. The reported treatment duration was 4 hr.
Limitations and Safety
Safety information: The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study. Although these data suggest that inhaled hydrogen gas may be well tolerated, future studies need to be powered to further evaluate safety.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.