Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
Toru Ishibashi, Bunpei Sato, Shinji Shibata, Takaaki Sakai, Yuichi Hara, Yuji Naritomi, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao · International immunopharmacology · 2014
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In 1 patients, iL-6 levels in the H₂ group significantly decreased in 4 weeks by 37.3 ± 62.0% compared to baseline, whereas it increased by 33.6 ± 34.4% in the placebo group. These findings add human evidence supporting molecular hydrogen's therapeutic potential for rheumatoid arthritis.
What the Findings Mean
H2HUBB reviewed how molecular hydrogen affected the outcomes measured in 1 patients. IL-6 levels in the H₂ group significantly decreased in 4 weeks by 37.3 ± 62.0% compared to baseline, whereas it increased by 33.6 ± 34.4% in the placebo group.
What the Researchers Studied
The researchers studied 1 patients. The study used a randomized, double-blind, placebo-controlled human clinical trial. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
IL-6 levels in the H₂ group significantly decreased in 4 weeks by 37.3 ± 62.0% compared to baseline, whereas it increased by 33.6 ± 34.4% in the placebo group.
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential for rheumatoid arthritis and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a randomized, double-blind, placebo-controlled human clinical trial. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The research population or model was 1 patients. The study used a randomized, double-blind, placebo-controlled human clinical trial.
Limitations and Safety
Safety information: The aim of this study was to demonstrate the safety and efficacy of H₂-saline infusion for treatment of rheumatoid arthritis (RA).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.