Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral hemorrhage: A case report and literature review.
Persistent vegetative state (PVS) is a devastating and long-lasting clinical condition with high morbidity and mortality; currently, there are no available effective interventions. We report the case of an 11-year-old boy with PVS caused by severe intracerebral bleeding in the left hemisphere following anticoagulation treatment. The patient's PVS severity showed no notable improvement after 2-mo neuroprotective treatment and rehabilitation, including nerve growth factor and baclofen, hyperbaric oxygen, and comprehensive bedside rehabilitation therapies.
Read MoreRole of hydrogen in traumatic brain injury: a narrative review.
Traumatic brain injury (TBI) is a serious global public health problem. Survivors of TBI often suffer from long-term disability, which puts a heavy burden on society and families. Unfortunately, up to now, there is no efficacious treatment for TBI patients in clinical practice.
Read MoreHydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves a key role in inflammatory response, which may lead to endothelial cell injury and blood-brain barrier (BBB) disruption. Hydrogen (H) is considered a neuroprotective antioxidant.
Read MoreHydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage
This animal study examined Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results of this study demonstrate that hydrogen-rich saline improves neurological outcomes in mice and reduces neuronal death by protecting against neural autophagy and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCase Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete
Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are available concerning its value as a first-aid intervention after a mild TBI.
Read MoreInhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest
This animal study examined Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest. The abstract describes Rat model; reported duration 1 hour. The abstract reports: Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy
This animal study examined Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy. The abstract describes Animal model. The abstract reports: In vitro results showed that PDA@ZIF-8@AB nanoparticles can release H continuously for up to 5 days in an acidic microenvironment, while the photothermal properties…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSkin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow‐up for 2 months
This case report or case series examined Skin ulcers infected with conditional pathogenic strains treated with local hydrogen water packing in two pemphigus vulgaris patients: Case reports with follow‐up for 2 months. The abstract describes Human participants; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreBeneficial effects of hydrogen-rich saline on early burn-wound progression in rats.
This animal study examined Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen can attenuate early wound progression following deep burn injury. The beneficial effect of hydrogen was mediated by attenuating oxidative stress, which inhibited apoptosis…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition.
This in vitro or cellular study examined Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition. The abstract describes Epithelial cell model. The abstract reports: We have discovered a novel pattern of wound healing induced by molecular hydrogen treatment. This is the first time to reveal the direct link between…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAtomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo.
This animal study examined Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. The abstract describes Animal model. The abstract reports: We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro.
This uncontrolled human study examined Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: HW intake via TF was demonstrated, for severely hospitalized elderly patients with PU, to execute wound size reduction and early recovery, which potently ensue…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap.
This animal study examined Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePositive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques.
This controlled human trial examined Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Our findings suggested that hydrogen-water bathing therapy could fulfill the unmet need for these chronic inflammatory skin diseases. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model.
This animal study examined Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and…. This is an automated editorial draft based on the abstract and requires source review before publication.
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