Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat Schwann cells in vitro.
Diabetic peripheral neuropathy (DPN) is considered to be the most common cause of microvascular diabetic complications, for which no effective therapies currently exist. Previous studies have identified that oxidative stress is the common pathway in all possible hypotheses for the induction of DPN, and poly(ADP‑ribose) (PAR) polymerase‑1 (PARP‑1)‑dependent cell death (parthanatos) is key in the pathogenic mechanisms of neurodegenerative disease. The aim of the present study was to investigate the protective effects and corresponding mechanisms of hydrogen‑rich medium (HM) on high glucose (HG)‑induced oxidative stress and parthanatos in primary rat…
Read MoreHydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
This uncontrolled human study examined Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: The present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreUse of molecular hydrogen as an energy substrate by human pathogenic bacteria.
This animal study examined Use of molecular hydrogen as an energy substrate by human pathogenic bacteria. The abstract describes Mouse model. The abstract reports: Pathogenic Helicobacter species (Helicobacter pylori and H. hepaticus) have the ability to use H(2) through a respiratory hydrogenase, and it was demonstrated that the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic effects of hydrogen-rich solution on aplastic anemia in vivo.
This animal study examined Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. The abstract describes Mouse model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Our study firstly showed that hydrogen-rich solution accelerated the recovery of either hematological or immunological recovery on aplastic anemia mice. This finding suggests hydrogen-rich…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreNeuroprotective and Preventative Effects of Molecular Hydrogen.
This animal study examined Neuroprotective and Preventative Effects of Molecular Hydrogen. The abstract describes Mouse model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms.
This animal study examined Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen water and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreDirect Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions
Molecular hydrogen (H) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H has multiple functions in addition to antioxidant effects, including antiinflammatory, anti-allergic functions, and as cell death and autophagy regulation.
Read MoreHydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
Numerous studies have examined the potential use of therapeutic gases for the treatment of various neurological disorders. Hydrogen gas, a promising neuroprotective agent, has been a focus of study due to its potent antioxidative properties. In translational research into adult diseases, hydrogen has been shown to be neuroprotective in disorders such as cerebral ischemia and traumatic brain injury, and in neurodegenerative diseases such as Alzheimer's disease.
Read MoreConsumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice
This animal study examined Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSi-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission
This animal study examined Si-Based Hydrogen-Producing Nanoagent Protects Fetuses From Miscarriage Caused by Mother-to-Child Transmission | Medical Technology. The abstract describes Mouse model. The abstract reports: Such transmissions can result in infections and diseases in infants or the induction of an inflammatory immune response through the placenta. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model.
This animal study examined Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. The abstract describes Rat model. The abstract reports: These results support the theory that H has a potential benefit in the prevention of preeclampsia. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen resuscitation, a new cytoprotective approach.
1. Hydrogen is a colourless, odourless, tasteless and flammable gas. Hydrogen is considered a physiologically inert gas and is often used in deep sea diving medicine.
Read MoreCirculating messenger for neuroprotection induced by molecular hydrogen.
This in vitro or cellular study examined Circulating messenger for neuroprotection induced by molecular hydrogen. The abstract describes Cell culture / in vitro model. The abstract reports: Molecular hydrogen (H) showed protection against various kinds of oxidative-stress-related diseases. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreStructural and lipid peroxidation effects of lead on rat hippocampus and its attenuation by hydrogen rich water.
This animal study examined Structural and lipid peroxidation effects of lead on rat hippocampus and its attenuation by hydrogen rich water. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 8 weeks. The abstract reports: Results showed that HRW corrected the elevated malondialdehyde levels (MDA) and restore the lead-induced depletion of antioxidant enzymes; glutathione reductase (GR), catalase (CAT) and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice.
This uncontrolled human study examined Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen water prevented abnormal body mass gain that is commonly observed in mdx mice. Hydrogen improved the spontaneous running distance that was estimated by…. This is an automated editorial draft based on the abstract and requires source review before publication.
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