Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig.
This animal study examined Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig. The abstract describes Animal model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress.
This animal study examined Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress. The abstract describes Rat model; sample size 60; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMitigating radiation-induced brain injury via NLRP3/NLRC4/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water.
This uncontrolled human study examined Mitigating radiation-induced brain injury via NLRP3/NLRC4/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Particularly, hydrogen-rich water showed a promising reduction in these symptoms. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLong-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights.
This animal study examined Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 60 days. The abstract reports: Histological results revealed that HRW reduced neuronal swelling, degeneration, and loss and enhanced dendritic spine density and neurogenesis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes
This in vitro or cellular study examined Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes. The abstract describes HaCaT keratinocyte model. The abstract reports: Our results showed that H exerted cytoprotective effects against stress induced by HO, t-BuOOH, and glyoxal. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePositive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease
This animal study examined Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease. The abstract describes Rat model. The abstract reports: In conclusion, the PD animal model showed increased intestinal permeability together with hepatic inflammation correlated with altered gut microbiota. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRandomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study
Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H) functions as a highly effective antioxidant in animal models of PD. A placebo-controlled, randomized, double-blind, parallel-group clinical pilot study was conducted to assess the efficacy of hydrogen gas inhalation in Japanese patients with PD on treatment with levodopa.
Read MoreTherapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease
This in vitro or cellular study examined Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease. The abstract describes Cell culture / in vitro model. The abstract reports: Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics.
Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Changes in the total UPDRS scores from baseline to the 8(th), 24(th), 48(th), and 72(nd) weeks, and after the 8(th) week, will be evaluated.
Read MoreMolecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease.
This animal study examined Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial
Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson's features in model animals.
Read MoreInhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease.
Hyposmia is one of the earliest and the most common symptoms in Parkinson's disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinary 8-hydroxy-2'-deoxyguanine (8-OHdG) levels by a randomized, double-blinded, placebo-controlled, crossover trial with an 8-week washout period in 20 patients with PD.
Read MoreHydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
This animal study examined Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. The abstract describes Mouse model. The abstract reports: The concentration-dependency of H(2) showed that H(2) as low as 0.08 ppm had almost the same effect as saturated H(2) water (1.5 ppm). This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRealizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease.
This case report or case series examined Realizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 35 years. The abstract reports: Fox Foundation has been funding research on Parkinson's disease for 35 years, but has yet to find a cure. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRole and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by a pathology that includes the aggregation of alpha-synuclein (α-syn), oxidative stress, and neuroinflammation. While existing treatments can alleviate motor symptoms, they have limited efficacy in slowing disease progression and improving non-motor symptoms. In recent years, molecular hydrogen has been recognized for its potential neuroprotective effects, attributed to its selective antioxidant and anti-inflammatory properties.
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