Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice.
This animal study examined Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Given the known contributions of oxidative stress caused by reactive oxygen species (ROS) and selective inhibition of potent ROS peroxynitrite and OH·by H gas…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.
This animal study examined Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. The abstract describes Mouse model. The abstract reports: Moreover, this result was consistent with the downregulation of expression of the oxidative stress hallmark OGG1. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAn Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress
Corneal alkali burns are potentially blinding injuries. Alkali induces oxidative stress in corneas followed by excessive corneal inflammation, neovascularization, and untransparent scar formation. Molecular hydrogen (H), a potent reactive oxygen species (ROS) scavenger, suppresses oxidative stress and enables corneal healing when applied on the corneal surface.
Read MoreProtective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression
This animal study examined Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: Our findings demonstrate that inhalation of hydrogen gas could alleviate retinal oedema, shorten reopen time and improve retinal function, and the potential mechanism might…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
This in vitro or cellular study examined Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: This result likely occurs by inhibiting the activation of glial cells, decreasing the production of the iNOS and GRP78 and promoting glutamate clearance. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina.
This animal study examined Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. The abstract describes Rat model. The abstract reports: H2 reduces cellular peroxynitrite, a highly toxic reactive nitrogen species. Thus, H2 may be an effective and novel clinical tool for treating glaucoma and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.
This animal study examined Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury. The abstract describes Rat model; reported duration 60 minutes. The abstract reports: H(2) has no known toxic effects on the human body. Thus, the results suggest that H(2)-loaded eye drops are a highly useful neuroprotective and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.
This in vitro or cellular study examined Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. The abstract describes Cell culture / in vitro model. The abstract reports: The results in the present study indicate that miR-9, miR-199 and miR-21 play an important role in the anti-inflammatory regulation of LPS-activated microglia cells…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved
Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing.
Read MoreThe Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against -Methyl–Nitrosourea Induced Retinal Degeneration: A Topographic Study.
This animal study examined The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against -Methyl–Nitrosourea Induced Retinal Degeneration: A Topographic Study. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Particularly, the topographic measurements suggested that the IV delivery of HRS could alleviate MNU induced photoreceptor degeneration in the posterior retina. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats.
This animal study examined Effects of Post-Treatment Hydrogen Gas Inhalation on Uveitis Induced by Endotoxin in Rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation and oxyhydrogen. The abstract reports: RESULTS No statistically significant differences existed in the graded score of uveitis and the b-wave peak time in the Dark-adapted 3.0 ERG among the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effect of saturated hydrogen saline against blue light-induced retinal damage in rats.
This animal study examined Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. The abstract describes Rat model; sample size 30; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 6 hours. The abstract reports: Saturated hydrogen saline could protect the retina from light-induced damage by attenuating oxidative stress. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage.
This animal study examined Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage. The abstract describes Rabbit model. The abstract reports: We previously found that UVB irradiation of the cornea caused the imbalance between the antioxidant and prooxidant enzymes in the corneal epithelium, followed by…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePostconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury.
This animal study examined Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: HE and CTB tracing showed that the survival rate of RGCs in the H2-treated group was significantly higher than the rate in the I/R…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush.
This animal study examined Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 14 days. The abstract reports: These results demonstrated that H₂ protects RGCs and helps preserve the visual function after ONC and had a neuroprotective effect in a rat model…. This is an automated editorial draft based on the abstract and requires source review before publication.
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