A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level.
Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Kumi Kaneko, Atsunori Nakao, Takashi Imaoka · Medical gas research · 2012
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
The HC rapidly decreased to 10% of the plateau level in about 6 min and 18 min in arterial and venous blood, respectively after H₂ inhalation was discontinued. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
What the Publication Examined
For the feasibility of H₂ treatment in these patients, delivery of H₂ by inhalation method needs to be checked for consistency.
How Molecular Hydrogen Was Addressed
Hydrogen concentration (HC) in the arterial and venous blood was measured by gas chromatography on 3 patients, before, during and after 4% (case 1) and 3% (case2,3) H₂ gas inhalation with simultaneous monitoring of physiological parameters. For a consistency study, HC in the venous blood of 10 patients were obtained on multiple occasions at the end of 30-min H₂ inhalation treatment.
What the Publication Reported
The HC rapidly decreased to 10% of the plateau level in about 6 min and 18 min in arterial and venous blood, respectively after H₂ inhalation was discontinued.
Authors’ Conclusion
However, the consistency of H₂ delivery by inhalation needs to be improved.