A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
Tyler W LeBaron, Branislav Kura, Barbora Kalocayova, Narcis Tribulova, Jan Slezak · Molecules (Basel, Switzerland) · 2019
Research-use notice
Independent study record
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H2HUBB TAKEAWAY
This narrative review examined the available evidence on molecular hydrogen. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
The review examined a New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
Main Findings Across the Literature
Recently, molecular hydrogen has been investigated in preclinical and clinical studies on various diseases associated with oxidative and inflammatory stress such as radiation-induced heart disease, ischemia-reperfusion injury, myocardial and brain infarction, storage of the heart, heart transplantation, etc. Hydrogen is primarily administered via inhalation, drinking hydrogen-rich water, or injection of hydrogen-rich water. Although H₂ appears to be an important biological molecule with anti-oxidant, anti-inflammatory, and anti-apoptotic effects, the exact mechanisms of action remain elusive. There is no reported clinical toxicity; however, some data suggests that H₂ has a mild hormetic-like effect, which likely mediate some of its benefits.
H₂ Mechanisms / Biological Findings
Recently, molecular hydrogen has been investigated in preclinical and clinical studies on various diseases associated with oxidative and inflammatory stress such as radiation-induced heart disease, ischemia-reperfusion injury, myocardial and brain infarction, storage of the heart, heart transplantation, etc.
Authors’ Conclusion
The authors concluded that the mechanistic data, coupled with the pre-clinical and clinical studies, suggest that H₂ may be useful for ROS/inflammation-induced cardiotoxicity and other conditions.