A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
Tyler W LeBaron, Branislav Kura, Barbora Kalocayova, Narcis Tribulova, Jan Slezak · Molecules (Basel, Switzerland) · 2019
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined the available molecular-hydrogen literature. The authors highlighted early evidence of cytoprotective, antioxidant, and anti-inflammatory effects. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. It also was demonstrated that repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors of mice.
What the Researchers Studied
The authors reviewed a New Approach for the Prevention and Treatment of Cardiovascular Disorders.
What Effects Did Molecular Hydrogen Have?
One of the earliest therapeutic applications of H₂ was published in the 1970s, wherein mice with skin-transplanted tumors were treated with hyperbaric hydrogen, which resulted in marked regression of the tumors [ 98 ]. Inhalation of H₂ or the administration of HRW can increase the concentration of H₂ in arterial and venous blood in proportion to the administered dose [ 106 ]. Inhalation of H₂ gas leads to a plasma concentration that is in accordance with Henry’s law, which suggests that a 2% concentration of H₂ results in approximately a 15.6 μM H₂ concentration in the blood. It also was demonstrated that repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors of mice. The authors concluded that the mechanistic data, coupled with the pre-clinical and clinical studies, suggest that H₂ may be useful for ROS/inflammation-induced cardiotoxicity and other conditions. Recently, molecular hydrogen has been investigated in preclinical and clinical studies on various diseases associated with oxidative and inflammatory stress such as radiation-induced heart disease, ischemia-reperfusion injury, myocardial and brain infarction, storage of the heart, heart transplantation, etc. The biological effects of hydrogen have been attributed to major molecular mechanisms: (1) specific scavenging activity of hydroxyl radicals and peroxynitrite (2) reduction of inflammatory reactions (3) modulation of signal transduction (4) alterations of gene expressions In addition to the direct effect of H₂ on scavenging of • OH, the reduction in inflammation may also be due to the mechanism of gene expression change.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.