A Systematic Review of Molecular Hydrogen Therapy in Cancer Management.
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, Chai Hong Yeong · Asian Pacific journal of cancer prevention : APJCP · 2023
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
Jing Chu et al., 2021 Cervical cancer Independent H₂ study in vitro & in vivo Hydrogen gas (67% H₂) 7 days – Treatment with hydrogen promoted apoptosis while decreasing cell growth and oxidative stress. – Tumour growth and cell proliferation was reduced, along with increased cell death. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. Jing Chu et al., 2021 Cervical cancer Independent H₂ study in vitro & in vivo Hydrogen gas (67% H₂) 7 days – Treatment with hydrogen promoted apoptosis while decreasing cell growth and oxidative stress. – Tumour growth and cell proliferation was reduced, along with increased cell death.
What the Researchers Studied
The authors reviewed this review summarises the findings from various articles on the mechanism, treatment outcomes, and overall effectiveness of H₂ therapy on cancer management.
What Effects Did Molecular Hydrogen Have?
The inclusion criteria for this review are full-text research studies focusing on H₂ therapy and its effects on cancer, published within the past 10 years (2011 to 2021) and written in English. Extraction of data was based on the baseline characteristics of the eligible research reports following the selection criteria, i.e., general details of the study (author, country, study design), H₂ form of administration, duration of therapy along with their general findings and conclusions. Jing Chu et al., 2021 Cervical cancer Independent H₂ study in vitro & in vivo Hydrogen gas (67% H₂) 7 days – Treatment with hydrogen promoted apoptosis while decreasing cell growth and oxidative stress. – Tumour growth and cell proliferation was reduced, along with increased cell death. The authors concluded that although more comprehensive research is needed, given the promising outcomes, H₂ is worth considering for use as a complement to current cancer therapy. Molecular hydrogen (H₂) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (systematic review).
Technical Study Details
H2HUBB classifies this publication as systematic review with review or synthesis evidence. The study used a systematic review. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.