Accurate in vivo real-time determination of the hydrogen concentration in different tissues of mice after hydrogen inhalation.
Wenjun Zhu, Qianqian Gu, Boyan Liu, Yanhong Si, Huirong Sun, Jingjie Zhong, Yi Lu, Dan Wang, Junli Xue, Shucun Qin · Heliyon · 2022
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, the H₂ saturation concentrations varied among tissues significantly regardless of the concentration of H₂ inhaled, and they were detected the highest in the kidney but the lowest in the gastrocnemius. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. The H₂ saturation concentrations varied among tissues significantly regardless of the concentration of H₂ inhaled, and they were detected the highest in the kidney but the lowest in the gastrocnemius.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Here, sequential changes of H₂ concentrations in different tissues of another most commonly used experimental rodent mice were monitored in real time with an electrochemical H₂ gas sensor during continuous different concentrations of H₂ inhalation targeting on five tissues including brain, liver, spleen, kidney, and gastrocnemius. The H₂ saturation concentrations varied among tissues significantly regardless of the concentration of H₂ inhaled, and they were detected the highest in the kidney but the lowest in the gastrocnemius.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.