Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis.
Shengjian Fang, Xinqian Li, Xian Wei, Yu Zhang, Zhaoxin Ma, Youzhen Wei, Weihua Wang · Experimental and therapeutic medicine · 2018
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In female BALB/c mice, mice in the AR + H₂ group exhibited a 0.60±0.21 g weight gain, which was significantly higher compared with the weight gain in the AR group (0.23±0.24 g; P=0.008). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in female BALB/c mice. Mice in the AR + H₂ group exhibited a 0.60±0.21 g weight gain, which was significantly higher compared with the weight gain in the AR group (0.23±0.24 g; P=0.008).
What the Researchers Studied
The researchers studied female BALB/c mice. The study used a preclinical animal experiment. The comparison condition was control condition or baseline measurements.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen exposure: 240 minutes/day. Mice in the AR + H₂ group exhibited a 0.60±0.21 g weight gain, which was significantly higher compared with the weight gain in the AR group (0.23±0.24 g; P=0.008). The authors concluded that it has been previously indicated that oxidative stress may contribute to allergic inflammation, including AR. Although molecular hydrogen (H₂), an antioxidative agent, has been effective in treatment of numerous oxidative stress-associated diseases, the effect of inhalation of a high concentration of H₂ on AR remains unknown. H₂ can significantly increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) in epithelial cells and Nrf2 is the key molecule of antioxidative stress of hydrogen ( 34, 35 ).
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was female BALB/c mice. The reported sample size was 106. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen exposure was 240 minutes/day.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.