Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis.
Yiting Li, Renjie Bing, Meng Liu, Zhangyuting Shang, Yan Huang, Kaixiang Zhou, Dapeng Bao, Junhong Zhou · Frontiers in nutrition · 2024
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In participants, it was observed that compared to placebo, the effects of H₂ on oxidative stress (diacron-reactive oxygen metabolites, d-ROMs) was not significant (SMD = -0.01, 95%CI-0.42 to 0.39, p = 0.94). These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation in healthy adults.
What the Findings Mean
H2HUBB reviewed how multiple hydrogen delivery methods (hydrogen-rich water, saline infusion) was evaluated in this publication and summarizes the source-grounded findings below. It was observed that compared to placebo, the effects of H₂ on oxidative stress (diacron-reactive oxygen metabolites, d-ROMs) was not significant (SMD = -0.01, 95%CI-0.42 to 0.39, p = 0.94).
What the Researchers Studied
The study used a meta analysis. The comparison condition was placebo.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 68% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 68% source-reported H₂ gas concentration. It was observed that compared to placebo, the effects of H₂ on oxidative stress (diacron-reactive oxygen metabolites, d-ROMs) was not significant (SMD = -0.01, 95%CI-0.42 to 0.39, p = 0.94). The authors concluded that H₂ supplementation can help enhance antioxidant potential capacity in healthy adults, especially in intermittent exercise, but not directly diminish the levels of exercise-induced oxidative stress. Hydrogen (H₂) can selectively reduce excessive free radicals, but studies observed its "dual effects" on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. The following keywords were used for search strategy: ["hydrogen"[Mesh] or "molecular hydrogen" or "hydrogen rich water" or "hydrogen-rich water" or "hydrogen rich saline"] and ["Oxidative Stress"[Mesh] or "Antioxidative Stress" or "Oxidative Damage" or "Oxidative Injury" or "Oxidative Cleavage"] and ["randomized controlled trial"[Mesh] or "randomized" or "RCT"].
Why These Findings Matter
These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence oxidative-stress regulation in healthy adults and contribute to the growing body of molecular-hydrogen research.
How Strong Is This Evidence?
This is human clinical evidence from a meta analysis. H2HUBB interprets the findings in the context of the study design, sample, comparator, and measured outcomes rather than using one publication as a verdict on hydrogen therapy.
Technical Study Details
H2HUBB classifies this publication as human clinical study with human clinical evidence. The study used a meta analysis. The hydrogen delivery method was multiple hydrogen delivery methods (hydrogen-rich water, saline infusion). The source-reported hydrogen concentration was 68% source-reported H₂ gas concentration.
Limitations and Safety
Reported limitations: Due to the small sample size of each study, the Hedges’g was determined by subtracting the mean difference in outcomes of the control group from that of the intervention group post-intervention. The researchers assessed heterogeneity by measuring the inconsistency among the trial effects using the I 2 statistic. This level of heterogeneity was categorized using the Cochrane Collaboration’s guidelines: trivial if less than 25%, low for 25 to 50%, moderate between 50 and 75%, and high if above 75% ( 30 ).
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.