Combating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water.
Mustafa Oguz Cumaoglu, Mustafa Makav, Serpil Dag, Ayfer Yildiz Uysal, Lale Baser, Tyler W LeBaron, Duried Alwazeer · Tissue & cell · 2024
Research-use notice
Independent study record
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Neutral Summary
In rats, data showed that while MDA, TNF-α, IL-6, endocan, and endoglin, urea, and creatinine parameters increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Hydrogen Intervention
hydrogen-rich water
Additional Notes
H2HUBB TAKEAWAY
In rats, data showed that while MDA, TNF-α, IL-6, endocan, and endoglin, urea, and creatinine parameters increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined rats.
How Molecular Hydrogen Was Used
This study aims to examine the effects of hydrogen-rich water (HRW) on gentamicin-induced renal damage in rats. Thirty-two rats were equally divided into four groups, including control (no treatment), hydrogen, gentamicin, and gentamicin+hydrogen. Data showed that while MDA (control P<0.0001, H2P<0.0001, Genta+H2P<0.0007), TNF-α (control P<0.0002, H2P<0.0040, Genta+H2P<0.0381), IL-6 (control P<0.0044, H2P<0.0070, Genta+H2P<0.0109), endocan (control P<0.0460, H2P<0.0286, Genta+H2P<0.0452), and endoglin (control P<0.0131, H2P<0.0164, Genta+H2P<0.0397), urea (control P<0.0024, H2P<0.0001, Genta+H2P<0.0180), and creatinine parameters (control P<0.0017, H2P<0.0178, Genta+H2P<0.0011) increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group.
What the Researchers Found
Data showed that while MDA (control P<0.0001, H2P<0.0001, Genta+H2P<0.0007), TNF-α (control P<0.0002, H2P<0.0040, Genta+H2P<0.0381), IL-6 (control P<0.0044, H2P<0.0070, Genta+H2P<0.0109), endocan (control P<0.0460, H2P<0.0286, Genta+H2P<0.0452), and endoglin (control P<0.0131, H2P<0.0164, Genta+H2P<0.0397), urea (control P<0.0024, H2P<0.0001, Genta+H2P<0.0180), and creatinine parameters (control P<0.0017, H2P<0.0178, Genta+H2P<0.0011) increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group. Immunohistochemically, 8-OHdG, MDA, and Bax expressions increased in the gentamicin group compared to the control group, whereas they decreased in the gentamicin+hydrogen group compared to the gentamicin group.
H₂ Mechanisms / Biological Findings
Hydrogen may be an alternative treatment for oxidative stress-induced nephrotoxicity.
Authors’ Conclusion
A distinct authors’ conclusion was not available in the source material reviewed by H2HUBB.