Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model.
Yunchuan Hong, L I Sun, Ruiqiang Sun, Hongguang Chen, Yonghao Yu, Keliang Xie · Experimental and therapeutic medicine · 2016
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In an animal model, the inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of ZY-challenged mice from 20 to 70 or 60%, respectively. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
The study examined preclinical animal experiment.
How Molecular Hydrogen Was Used
inhaled hydrogen gas.
What the Researchers Found
The inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of ZY-challenged mice from 20 to 70 or 60%, respectively. However, combination therapy with H₂ and hyperoxia could increase the 14-day survival rate of ZY-challenged mice to 100%. Combination therapy of H₂ and hyperoxia has previously been shown to significantly improve survival rate and organ damage extent in mice with polymicrobial sepsis.
H₂ Mechanisms / Biological Findings
Reported molecular-hydrogen-related mechanisms included hydrogen gas (H₂) exerts a therapeutic antioxidative effect by selectively reducing ROS.
Authors’ Conclusion
The authors concluded that , combination therapy with H₂ and hyperoxia provides enhanced therapeutic efficacy against multiple organ damage in a ZY-induced generalized inflammation model, suggesting the potential applicability of H₂ and hyperoxia in the therapy of conditions associated with inflammation-related MODS.