Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
Keliang Xie, Wenzheng Fu, Weibin Xing, Ailin Li, Hongguang Chen, Huanzhi Han, Yonghao Yu, Guolin Wang · Shock (Augusta, Ga.) · 2012
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In the present study, the researchers found that inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of septic mice with moderate cecal ligation and puncture (CLP) from 40% to 80% or 70%, respectively. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in mice. In the present study, the researchers found that inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of septic mice with moderate cecal ligation and puncture (CLP) from 40% to 80% or 70%, respectively.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 98% source-reported H₂ gas concentration; Source-reported hydrogen exposure: 98% source-reported H₂ gas concentration. In the present study, the researchers found that inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of septic mice with moderate cecal ligation and puncture (CLP) from 40% to 80% or 70%, respectively. The authors concluded that recently, it has been suggested that molecular hydrogen (H₂) at low concentration can exert a therapeutic antioxidant activity and effectively protect against sepsis by reducing oxidative stress.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas. The source-reported hydrogen concentration was 98% source-reported H₂ gas concentration.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base. The original scholarly source is available at https://www.ovid.com/jnls/shockjournal/abstract/10.1097/shk.0b013e3182758646~combination-therapy-with-molecular-hydrogen-and-hyperoxia-in?redirectionsource=fulltextview.