Consumption of hydrogen-rich water ameliorates atherosclerosis by modulating gut microbiota and enhancing short-chain fatty acid levels.
Fanxianzi Meng, Minghai Xue, Huili Li, Geru Tao, Wei Chen, Yuanmin Li, Hui Pei, Zhichao Liu, Deling Yin, Shucun Qin, Junli Xue, Boyan Liu · Life sciences · 2026
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, kEY FINDINGS: H2W consumption significantly attenuated plaque formation and enhanced plaque stability in ApoE-/- mice, accompanied by altered gut microbiota structure and short-chain fatty acid profiles. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in mice. KEY FINDINGS: H2W consumption significantly attenuated plaque formation and enhanced plaque stability in ApoE-/- mice, accompanied by altered gut microbiota structure and short-chain fatty acid profiles.
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
KEY FINDINGS: H2W consumption significantly attenuated plaque formation and enhanced plaque stability in ApoE-/- mice, accompanied by altered gut microbiota structure and short-chain fatty acid profiles. Molecular hydrogen (H₂) is a safe gaseous signaling molecule with anti-inflammatory properties.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.