Decompression sickness risk in rats by microbial removal of dissolved gas.
S R Kayar, T L Miller, M J Wolin, E O Aukhert, M J Axley, L A Kiesow · The American journal of physiology · 1998
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In rats, thus using a microbe in the intestine to remove an estimated 5% of the body burden of H₂ reduced DCS risk by more than one-half. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how inhaled hydrogen gas affected the outcomes measured in rats. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H₂ reduced DCS risk by more than one-half.
What the Researchers Studied
The researchers studied rats. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H₂ pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H₂ stored in the rats' tissues. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H₂ reduced DCS risk by more than one-half.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was rats. The study used a preclinical animal experiment. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the current-study source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.