Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in bilateral kidneys-effects of hydrogen gas inhalation.
Yoshitaka Kinoshita, Kohsuke Shirakawa, Motoaki Sano, Takashi Yokoo, Haruki Kume, Eiji Kobayashi · Translational andrology and urology · 2022
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Independent study record
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H2HUBB TAKEAWAY
In an animal model, although the effect of hydrogen gas on pathological findings was not obvious, the release of degraded DNA from the kidney, an acute marker of IRI, appeared to be suppressed. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
What the Researchers Studied
It has been reported that prolonged renal ischemia time in pigs for 120 min or more can cause irreversible renal damage and increase animal mortality.
How Molecular Hydrogen Was Used
Using this novel model, the researchers investigated whether hydrogen gas inhalation could alleviate renal IRI.
What the Researchers Found
Although the effect of hydrogen gas on pathological findings was not obvious, the release of degraded DNA from the kidney, an acute marker of IRI, appeared to be suppressed.
Authors’ Conclusion
The authors concluded that have developed a novel model in which IRI of different ischemia times is induced in the bilateral kidney that provides two-fold information and allows for safe long-term observation experiments in pigs. Using this model, hydrogen gas inhalation appeared to reduce acute renal IRI, although the effect was not statistically significant. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.