DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis.
Yuanyuan Bai, Zeyu Li, Donglai Yan, Yi Jiang, Beibei Dong, Yonghao Yu · Brain and behavior · 2025
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
This narrative review examined metabolomic and phosphoproteomic analyses were utilized to explore the therapeutic mechanism of H₂. The WB and IF results revealed that DGKζ expression increased in septic mice but decreased after H₂ treatment. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
What the Findings Mean
H2HUBB reviewed this publication as a synthesis of molecular-hydrogen research and summarizes the outcomes emphasized by the authors. The WB and IF results revealed that DGKζ expression increased in septic mice but decreased after H₂ treatment.
What the Researchers Studied
The authors reviewed metabolomic and phosphoproteomic analyses were utilized to explore the therapeutic mechanism of H₂.
What Effects Did Molecular Hydrogen Have?
Caecal ligation and puncture (CLP) was used to establish an animal model of sepsis, after which the animals were treated with hydrogen. The WB and IF results revealed that DGKζ expression increased in septic mice but decreased after H₂ treatment. The authors concluded that H₂ downregulates the levels of DGKζ and CCTα to alleviate brain damage in septic mice, and changes in DGKζ expression are balancing the transformation between the DAG anf PA, and it might also interact with PTEN. Therapeutic effects of hydrogen (H₂) on sepsis-associated encephalopathy (SAE), a severe neuroinflammatory disease, have been reported, but the underlying mechanism remains unclear.
Why These Findings Matter
The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
How Strong Is This Evidence?
This is review or synthesis evidence (narrative review).
Technical Study Details
H2HUBB classifies this publication as narrative review with review or synthesis evidence. The study used a narrative review. The hydrogen delivery method was inhaled hydrogen gas.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.