DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis.
Yuanyuan Bai, Zeyu Li, Donglai Yan, Yi Jiang, Beibei Dong, Yonghao Yu · Brain and behavior · 2025
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Independent study record
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H2HUBB TAKEAWAY
This narrative review examined metabolomic and phosphoproteomic analyses were utilized to explore the therapeutic mechanism of H₂. The WB and IF results revealed that DGKζ expression increased in septic mice but decreased after H₂ treatment. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
What the Review Examined
Metabolomic and phosphoproteomic analyses were utilized to explore the therapeutic mechanism of H₂.
Main Findings Across the Literature
The WB and IF results revealed that DGKζ expression increased in septic mice but decreased after H₂ treatment.
Authors’ Conclusion
The authors concluded that H₂ downregulates the levels of DGKζ and CCTα to alleviate brain damage in septic mice, and changes in DGKζ expression are balancing the transformation between the DAG anf PA, and it might also interact with PTEN.