Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity.
Masaaki Nakayama, Wan-Jun Zhu, Kimio Watanabe, Ayano Gibo, Ali M Sherif, Shigeru Kabayama, Sadayoshi Ito · BMC nephrology · 2017
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Independent study record
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H2HUBB TAKEAWAY
In Parietal peritoneum samples and cells collected from the peritoneal surface following treatment with trypsin were subjected to analysis, clinical application of H₂ in PD could be a novel strategy for protection of peritoneal tissue during PD treatment. The authors concluded that clinical application of H₂ in PD could be a novel strategy for protection of peritoneal tissue during PD treatment. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In the present study, the researchers aimed to examine the effects of H₂ on the peritoneal membrane of experimental PD rats.
Laboratory Model
Parietal peritoneum samples and cells collected from the peritoneal surface following treatment with trypsin were subjected to analysis.
How Molecular Hydrogen Was Used
Eight-week-old male Sprague-Dawley rats were divided into the following groups (n = 8-11 each) receiving different test solutions: control group (no treatment), PD group (commercially available lactate-based neutral 2.5% glucose PD solution), and H2PD group (PD solution with dissolved H₂ at 400 ppb).
What Molecular Hydrogen Changed
Clinical application of H₂ in PD could be a novel strategy for protection of peritoneal tissue during PD treatment.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.