Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota.
Naqi Lian, Mengxi Shen, Kai Zhang, Jiacheng Pan, Yi Jiang, Yang Yu, Yonghao Yu · Journal of pain research · 2021
Research-use notice
Independent study record
Each H2HUBB study page organizes source-linked research details for educational use. Interpretation should remain proportional to the study design, population, controls, and limitations.
H2HUBB TAKEAWAY
In mice, following treatment with oxaliplatin, the expression of inflammatory cytokines TNF-α and IL-6 was significantly increased (P<0.05, H₂O + OXA vs H₂O + Saline; P<0.05, HW + OXA vs HW + Saline). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
What the Findings Mean
H2HUBB reviewed how hydrogen-rich water affected the outcomes measured in mice. Following treatment with oxaliplatin, the expression of inflammatory cytokines TNF-α and IL-6 was significantly increased (P<0.05, H₂O + OXA vs H₂O + Saline; P<0.05, HW + OXA vs HW + Saline).
What the Researchers Studied
The researchers studied mice. The study used a preclinical animal experiment.
What Effects Did Molecular Hydrogen Have?
Source-reported hydrogen concentration: 000 ppb H₂ (≈0 mg/L); Source-reported hydrogen exposure: 400 mL hydrogen-rich water per reported dose; approximately 0 mg H₂ per reported serving; reported treatment duration: 5 days. Following treatment with oxaliplatin, the expression of inflammatory cytokines TNF-α and IL-6 was significantly increased (P<0.05, H₂O + OXA vs H₂O + Saline; P<0.05, HW + OXA vs HW + Saline). The authors concluded that hydrogen-rich water may alleviate CINP by affecting the diversity and structure of the gut microbiota, and then the LPS-TLR4 pathway, which provides a direction for further research. The results illustrated that hydrogen-rich water could alleviate oxaliplatin-induced hyperalgesia, reduce the microbial diversity and alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4.
Why These Findings Matter
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
How Strong Is This Evidence?
This is preclinical animal evidence from a preclinical animal experiment. It is most informative for the disease model, mechanisms, biomarkers, and outcomes directly measured in the study.
Technical Study Details
H2HUBB classifies this publication as animal study with preclinical animal evidence. The research population or model was mice. The study used a preclinical animal experiment. The hydrogen delivery method was hydrogen-rich water. The source-reported hydrogen concentration was 000 ppb H₂ (≈0 mg/L). The source-reported hydrogen exposure was 400 mL hydrogen-rich water per reported dose; approximately 0 mg H₂ per reported serving. The reported treatment duration was 5 days.
Limitations and Safety
No separate limitations or safety findings were identified in the source text available to H2HUBB.
Original Study and H2HUBB Research Context
H2HUBB presents this source-grounded research record as one contribution to the broader molecular-hydrogen evidence base.