Effect of Hydrogen-Rich Water on Radiation-Induced Cognitive Dysfunction in Rats.
Mengya Liu, Hui Yuan, Jingjing Yin, Ruoqi Wang, Jianbo Song, Bo Hu, Jianguo Li, Xiujun Qin · Radiation research · 2020
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Independent study record
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H2HUBB TAKEAWAY
In Immunofluorescence staining was adopted to detect proliferating cells, compared to the radiation treated group, the radiation-HRW treated group showed significantly decreased escape latency (P < 0.05), but increased retention time, swimming distance of original platform quadrant (P < 0.05) and number of platform crossings (P < 0.05). The authors concluded that the study indicates that HRW has a protective effect on radiation-induced cognitive dysfunction, and that the possible mechanisms mainly involve anti-oxidative and anti-inflammatory reactions, and its protection of newborn neurons by regulating the BDNF-TrkB signaling pathway. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
What the Researchers Tested
In vitro cell-culture laboratory experiment.
Laboratory Model
Immunofluorescence staining was adopted to detect proliferating cells.
How Molecular Hydrogen Was Used
The goal of this work was to determine whether hydrogen-rich water (HRW) could attenuate radiation-induced cognitive dysfunction in rats and to explore the underlying mechanisms.
What Molecular Hydrogen Changed
Compared to the radiation treated group, the radiation-HRW treated group showed significantly decreased escape latency (P < 0.05), but increased retention time, swimming distance of original platform quadrant (P < 0.05) and number of platform crossings (P < 0.05).
Proposed Mechanism
The goal of this work was to determine whether hydrogen-rich water (HRW) could attenuate radiation-induced cognitive dysfunction in rats and to explore the underlying mechanisms.
Authors’ Conclusion
These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.